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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Tongue disease in advanced AIDS
Oral Diseases, Volume 11, No. 2, Year 2005
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Description
OBJECTIVE: This study describes the involvement and the histological alterations found in the tongues of 92 autopsied patients who died with AIDS. MATERIALS AND METHODS: Sex, age, CD4 cell count and clinical history were obtained from the files of 92 patients who died with AIDS. All the tongues were examined for macroscopical alterations and stained using H&E, Gomori-Grocott, Ziehl-Neelsen, PAS, Brow-Hopps and Mucicarmine. Histological autopsy findings were grouped based on a protocol that was designed following the World Health Organization recommendations. RESULTS: The mean age of the patients who died of AIDS and CD4 cell count were 36 years and 82 cells μL-1, respectively. Histological alterations of the tongues were found in 75% of the cadavers. The most common lesions were hairy leukoplakia (HL) (42 cases), candidosis (31 cases) and non-specific chronic glossitis (29 cases), followed by concomitant lesions (28 cases), non-specific chronic ulceration (17 cases), melanotic pigmentation (13 cases), herpes simplex (10 cases), lymphoepithelial cysts (two cases), cryptococcosis (two cases), mycobacteriosis (one case), histoplasmosis (one case), cytomegalovirus infection (one case) and non-Hodgkin Lymphoma (one case). HL with oral candidosis (n = 13) were the most common concomitant lesions. CONCLUSION: These findings indicate that the tongue is a favorite site to occurrence of reactive, infectious and concurrent lesions in the end-stage of AIDS patients. © 2005 Blackwell Munksgaard All rights reserved.
Authors & Co-Authors
Vargas, P. A.
Brazil, Campinas
Universidade Estadual de Campinas
Saldiva, Paulo Hilário
Brazil, Sao Paulo
Universidade de São Paulo
Mauad, Thais H.
Brazil, Sao Paulo
Universidade de São Paulo
Netherlands, Leiden
Leids Universitair Medisch Centrum
Almeida, Oslei Paes de
Brazil, Campinas
Universidade Estadual de Campinas
Statistics
Citations: 23
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1111/j.1601-0825.2004.01070.x
ISSN:
1354523X
Research Areas
Health System And Policy
Infectious Diseases