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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Stromal myofibroblasts in squamous cell carcinoma of the tongue in young patients - A multicenter collaborative study
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 118, No. 4, Year 2014
Notification
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Description
Objective The purpose of this study was to evaluate the presence of myofibroblasts, frequently associated with a more aggressive neoplastic behavior, in oral tongue squamous cell carcinoma (TSCC) of young patients and to compare with the distribution observed in older patients. Study Design Tumor samples from 29 patients younger than 40 years old affected by TSCC were retrieved and investigated for the presence of stromal myofibroblasts by immunohistochemical reactions against α smooth muscle actin, and the results obtained were compared to TSCC cases affecting older patients. Results No positive reaction could be found in the stromal areas devoid of neoplastic tissue, whereas myofibroblasts were present in 58.6% of the lesions in young patients and in 75.9% of the older ones. No significant difference was found when comparing the invasive front and the overall stroma of both groups, and no correlation could be obtained with stromal α smooth muscle actin expression, higher tumor grades or clinical stage (P >.05). Conclusion There was no significant difference between the presence of stromal myofibroblasts of TSCC affecting young and old individuals. © 2014 Elsevier Inc.
Authors & Co-Authors
Fonseca, Felipe Paiva
Brazil, Campinas
Universidade Estadual de Campinas
Coletta, Ricardo D.
Brazil, Campinas
Universidade Estadual de Campinas
Carlos-Bregni, Román
Guatemala, Guatemala City
Centro Clínico de Cabeza y Cuello
Farthing, Paula M.
United Kingdom, Sheffield
The University of Sheffield
Hunter, Keith D.
United Kingdom, Sheffield
The University of Sheffield
Speight, Paul M.
United Kingdom, Sheffield
The University of Sheffield
Vargas, P. A.
Brazil, Campinas
Universidade Estadual de Campinas
Almeida, Oslei Paes de
Brazil, Campinas
Universidade Estadual de Campinas
Lopes, Márcio Ajudarte
Brazil, Campinas
Universidade Estadual de Campinas
Santos-Silva, Alan Roger
Brazil, Campinas
Universidade Estadual de Campinas
Statistics
Citations: 12
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1016/j.oooo.2014.07.012
ISSN:
22124403
Research Areas
Cancer
Health System And Policy