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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Vitamin e and N-acetylcysteine as antioxidant adjuvant therapy in children with acute lymphoblastic leukemia
Advances in Hematology, Volume 2009, Article 689639, Year 2009
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Description
Although cancer therapies have experienced great success nowadays, yet the associated toxic response and free radicals formation have resulted in significant number of treatment-induced deaths rather than disease-induced fatalities. Complications of chemotherapy have forced physicians to study antioxidant use as adjunctive treatment in cancer. This study aimed to evaluate the antioxidant role of vitamin E and N-acetyl cysteine (NAC) in overcoming treatment-induced toxicity in acute lymphoblastic leukaemia (ALL) during the intensive period of chemo-/radiotherapy, almost the first two months of treatment. Forty children newly diagnosed with ALL were enrolled in this study. Twenty children (group I) have taken vitamin E and NAC supplementations with chemotherapy and the other twenty children (group II) have not taken any adjuvant antioxidant therapy. They were evaluated clinically for the occurrence of complications and by the laboratory parameters (blood levels of glutathione peroxidase (Glu.PX) antioxidant enzyme, malondialdehyde (MDA), tumor necrosis factor-α (TNF-α ), liver enzymes, and bone marrow picture). Results revealed reduced chemotherapy and radiotherapy toxicity as evidenced by decreasing level of MDA, increasing level of Glu.Px and decreased occurrence of toxic hepatitis, haematological complications, and need for blood and platelet transfusions in group I compared to group II. We can conclude that vitamin E and NAC have been shown to be effective as antioxidant adjuvant therapy in children with ALL to reduce chemo-/radiotherapy-related toxicities during the initial period of treatment. © 2009 Youssef Al-Tonbary et al.
Authors & Co-Authors
Al-Tonbary, Youssef Abdelhalim
Egypt, Mansoura
Faculty of Medicine
Al-Haggar, Mohammad
Egypt, Mansoura
Faculty of Medicine
El-Ashry, Rasha Abd Elmalk
Egypt, Mansoura
Faculty of Medicine
ElDakroory, Sahar A.
Egypt, Mansoura
Faculty of Medicine
Azzam, Hanan A.G.
Egypt, Mansoura
Faculty of Medicine
Fouda, Ashraf E.
Egypt, Mansoura
Faculty of Medicine
Statistics
Citations: 55
Authors: 6
Affiliations: 1
Identifiers
Doi:
10.1155/2009/689639
ISSN:
16879104
e-ISSN:
16879112
Research Areas
Cancer
Environmental
Infectious Diseases
Maternal And Child Health