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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Responses to pandemic ASO3-adjuvanted A/California/07/09 H1N1 influenza vaccine in human immunodeficiency virus-infected individuals
BMC Immunology, Volume 13, Article 49, Year 2012
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Description
Background: Influenza infection may be more serious in human immunodeficiency virus (HIV)-infected individuals, therefore, vaccination against seasonal and pandemic strains is highly advised. Seasonal influenza vaccines have had no significant negative effects in well controlled HIV infection, but the impact of adjuvanted pandemic A/California/07/2009 H1N1 influenza hemaglutinin (HA) vaccine, which was used for the first time in the Canadian population as an authorized vaccine in autumn 2009, has not been extensively studied.Objective: Assess vaccine-related effects on CD4+ T cell counts and humoral responses to the vaccine in individuals attending the Newfoundland and Labrador Provincial HIV clinic.Methods: A single dose of ArepanrixTM split vaccine including 3.75 μg A/California/07/2009 H1N1 HA antigen and ASO3 adjuvant was administered to 81 HIV-infected individuals by intramuscular injection. Plasma samples from shortly before, and 1-5 months after vaccination were collected from 80/81 individuals to assess humoral anti-H1N1 HA responses using a sensitive microbead-based array assay. Data on CD4+ T cell counts, plasma viral load, antiretroviral therapy and patient age were collected from clinical records of 81 individuals.Results: Overall, 36/80 responded to vaccination either by seroconversion to H1N1 HA or with a clear increase in anti-H1N1 HA antibody levels. Approximately 1/3 (28/80) had pre-existing anti-H1N1 HA antibodies and were more likely to respond to vaccination (22/28). Responders had higher baseline CD4+ T cell counts and responders without pre-existing antibodies against H1N1 HA were younger than either non-responders or responders with pre-existing antibodies. Compared to changes in their CD4+ T cell counts observed over a similar time period one year later, vaccine recipients displayed a minor, transient fall in CD4+ T cell numbers, which was greater amongst responders.Conclusions: We observed low response rates to the 2009 pandemic influenza vaccine among HIV-infected individuals without pre-existing antibodies against H1N1 HA and a minor transient fall in CD4+ T cell numbers, which was accentuated in responders. A single injection of the ArepanrixTM pandemic A/California/07/2009 H1N1 HA split vaccine may be insufficient to induce protective immunity in HIV-infected individuals without pre-existing anti-H1N1 HA responses. © 2012 Kelly et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Kelly, Deborah V.
Canada, St John's
Memorial University of Newfoundland
Canada, St John's
Eastern Health, Canada
Burt, Kimberley
Canada, St John's
Eastern Health, Canada
Missaghi, Bayan
Canada, St John's
Eastern Health, Canada
Canada, St John's
Memorial University of Newfoundland
Barrett, Lisa
United States, Bethesda
National Institutes of Health Nih
Keynan, Y.
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Fowke, Keith Raymond
Canada, Winnipeg
University of Manitoba
Kenya, Nairobi
University of Nairobi
Grant, Michael
Canada, St John's
Memorial University of Newfoundland, Faculty of Medicine
Canada, St John's
Memorial University of Newfoundland
Statistics
Citations: 7
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2172-13-49
e-ISSN:
14712172
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study