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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Synthesis, biopharmaceutical characterization, antimicrobial and antioxidant activities of 1-(4′-O-β-d-glucopyranosyloxy-2′- hydroxyphenyl)-3-aryl-propane-1,3-diones
European Journal of Medicinal Chemistry, Volume 46, No. 4, Year 2011
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Description
This research communication is toward the investigation of the antibacterial, antifungal and antioxidant activities of the synthesized compounds 1-(4′-O-β-d-glucopyranosyloxy-2′-hydroxyphenyl)-3- aryl-propane-1,3-diones (5a)-(5h). These compounds have been obtained by the interaction of α-acetobromoglucose with 1-(2′,4′- dihydroxyphenyl)-3-aryl-propane-1,3-diones (3a)-(3h) under anhydrous condition and at lower temperature. The structures of these newly synthesized O-β-d-glucopyranosides were established on the basis of chemical, elemental, and spectral analyses. Further, the compounds (5b), (5c), (5d) and (5g) showed potent antibacterial and antifungal activity. A good correlation was obtained between the theoretical predictions of bioavailability using Lipinski's rule-of-five and experimental verification. © 2011 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Sheikh, Javed I.
India, Nagpur
National Environmental Engineering Research Institute India
India, Nagpur
Rashtrasant Tukadoji Maharaj Nagpur University
Ali, Parvez S.
India, Nagpur
Rashtrasant Tukadoji Maharaj Nagpur University
Juneja, Harjeet D.
India, Nagpur
Rashtrasant Tukadoji Maharaj Nagpur University
Ingle, Vishwas N.
India, Nagpur
Rashtrasant Tukadoji Maharaj Nagpur University
Chohan, Zahid Hussain
Pakistan, Multan
Bahauddin Zakariya University
Youssoufi, Moulay Hfid
Morocco, Oujda
Université Mohammed Premier Oujda
Ben Hadda, Taibi
Morocco, Oujda
Université Mohammed Premier Oujda
Statistics
Citations: 55
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejmech.2011.01.068
ISSN:
02235234
e-ISSN:
17683254