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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Limonoid orthoacetates and antiprotozoal compounds from the roots of Pseudocedrela kotschyi
Journal of Natural Products, Volume 70, No. 1, Year 2007
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Description
The dicholoromethane extract of Pseudocedrela kotschyi root demonstrated marked antileishmanial properties in preliminary screening of extracts from 21 species commonly used in Malian traditional medicine. Phytochemical investigation of the active extract yielded three novel phragmalin-type limonoid orthoacetates (1-3), named kotschyins A-C, and the known compounds 7-deacetylgedunin (4) and 7-deacetyl-7-oxogedunin (5). The structures of 1-3 were elucidated by analytical methods including 1D- and 2D-NMR spectroscopy together with MS spectroscopy. The relative configurations of 1-3 were assigned on the basis of NOE correlations. The extract and the isolated compounds were tested for their antiprotozoal activities against Leishmania donovani, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, and Plasmodium falciparum as well as for cytotoxicity toward the L-6 cell line. The crude extract and the two gedunin derivatives exhibited good in vitro activity against all of these parasites. © 2007 American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Hay, Anne Emmanuelle
Switzerland, Geneva
Université de Genève
Ioset, Jean Robert
Switzerland, Geneva
Université de Genève
Ahua, Kouassi Maximin
Switzerland, Geneva
Université de Genève
Diallo, Drissa
Mali, Bamako
National Institute of Research in Public Health
Brun, Reto
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Hostettmann, Kurt
Switzerland, Geneva
Université de Genève
Statistics
Citations: 59
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1021/np0680230
ISSN:
01633864
Research Areas
Health System And Policy