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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia
BMC Neurology, Volume 11, Article 139, Year 2011
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Description
Background: Xenobiotics are neurotoxins that dramatically alter the health of the child. In addition, an inefficient detoxification system leads to oxidative stress, gut dysbiosis, and immune dysfunction. The consensus among physicians who treat autism with a biomedical approach is that those on the spectrum are burdened with oxidative stress and immune problems. In a trial to understand the role of detoxification in the etiology of autism, selected parameters related to sulfur-dependent detoxification mechanisms in plasma of autistic children from Saudi Arabia will be investigated compared to control subjects.Methods: 20 males autistic children aged 3-15 years and 20 age and gender matching healthy children as control group were included in this study. Levels of reduced glutathione (GSH), total (GSH+GSSG), glutathione status (GSH/GSSG), glutathione reductase (GR), glutathione- s-transferase (GST), thioredoxin (Trx), thioredoxin reductase (TrxR) and peroxidoxins (Prxs I and III) were determined.Results: Reduced glutathione, total glutathione, GSH/GSSG and activity levels of GST were significantly lower, GR shows non-significant differences, while, Trx, TrxR and both Prx I and III recorded a remarkably higher values in autistics compared to control subjects.Conclusion: The impaired glutathione status together with the elevated Trx and TrxR and the remarkable over expression of both Prx I and Prx III, could be used as diagnostic biomarkers of autism. © 2011 Al-Yafee et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Al-Yafee, Yusra A.
Saudi Arabia, Riyadh
College of Sciences
Al- Ayadhi, Laila Yousef
Saudi Arabia, Riyadh
Autism Research and Treatment Center
Saudi Arabia, Riyadh
King Saud University
Haq, Samina H.
Saudi Arabia, Riyadh
College of Sciences
El-Ansary, Afaf Kamal E.
Saudi Arabia, Riyadh
College of Sciences
Saudi Arabia, Riyadh
Autism Research and Treatment Center
Saudi Arabia, Riyadh
King Saud University
Statistics
Citations: 85
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1186/1471-2377-11-139
e-ISSN:
14712377
Research Areas
Disability
Maternal And Child Health
Noncommunicable Diseases
Study Design
Randomised Control Trial
Case-Control Study