Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Resveratrol, a red wine polyphenol, attenuates ethanol-induced oxidative stress in rat liver
Life Sciences, Volume 80, No. 11, Year 2007
Notification
URL copied to clipboard!
Description
The involvement of oxidative stress in the pathogenesis of alcoholic diseases in the liver has been repeatedly confirmed. Resveratrol, a natural phytoalexin present in grape skin and red wine possesses a variety of biological activities including antioxidant. This study was conducted to evaluate whether resveratrol has a preventive effect on the main indicators of hepatic oxidative status as an expression of the cellular damage caused by free radicals, and on antioxidant defence mechanism during chronic ethanol treatment. Wistar rats were treated daily with 35% ethanol solution (3 g/kg/day i.p.) during 6 weeks and fed basal diet or basal diet containing 5 g/kg resveratrol. Control rats were treated with i.p. saline and fed basal diet. Experimentally, chronic ethanol administration leads to hepatotoxicity as monitored by the increase in the level of hepatic marker enzymes and the appearance of fatty change, necrosis, fibrosis and inflammation in liver sections. Ethanol also enhanced the formation of MDA in the liver indicating an increase in lipid peroxidation, a major end-point of oxidative damage, and caused drastic alterations in antioxidant defence systems. Particularly the activities of hepatic superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were found reduced by ethanol treatment while glutathione reductase (GR) activity was unchanged. Dietary supplementation with resveratrol during ethanol treatment inhibited hepatic lipid peroxidation and ameliorated SOD, GPx and CAT activities in the liver. Conclusively, we can suggest that resveratrol could have a beneficial effect in inhibiting the oxidative damage induced by chronic ethanol administration, which was proved by the experiments that we conducted on rats. © 2007 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Kasdallah-Grissa, A.
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Mornagui, Bessem
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Aouani, Ezzedine
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Hammami, M. B.
Tunisia, Monastir
Faculté de Médecine de Monastir
El-May, Michèle Véronique
Tunisia, Tunis
Faculté de Médecine de Tunis
Gharbi, Najoua
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Kamoun, Abdelaziz
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
El-Fazaâ, Saloua
Tunisia, Tunis
Université de Tunis el Manar, Faculté Des Sciences de Tunis
Statistics
Citations: 237
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.lfs.2006.11.044
ISSN:
00243205