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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly
Diabetes Care, Volume 35, No. 3, Year 2012
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Description
OBJECTIVE - Impaired insulin sensitivity is linked to cognitive deficits and reduced brain size. However, it is not yet known whether insulin sensitivity involves regional changes in gray matter volume. Against this background, we examined the association between insulin sensitivity, cognitive performance, and regional gray matter volume in 285 cognitively healthy elderly men and women aged 75 years from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. RESEARCH DESIGN AND METHODS - Insulin sensitivity was calculated from fasting serum insulin and plasma glucose determinations using the homeostasis model assessment of insulin resistance (HOMA-IR) method. Cognitive performance was examined by a categorical verbal fluency. Participants also underwent a magnetic resonance imaging (MRI) brain scan. Multivariate analysis using linear regression was conducted, controlling for potential confounders (sex, education, serum LDL cholesterol, mean arterial blood pressure, and abdominal visceral fat volume). RESULTS - The HOMA-IR was negatively correlated with verbal fluency performance, brain size, and temporal lobe graymatter volume in regions known to be involved in speech production (Brodmann areas 21 and 22, respectively). No such effects were observed when examining diabetic (n = 55) and cognitively impaired (n = 27) elderly subjects as separate analyses. CONCLUSIONS - These cross-sectional findings suggest that both pharmacologic and lifestyle interventions improving insulin signaling may promote brain health in late life but must be confirmed in patient studies. © 2012 by the American Diabetes Association.
Authors & Co-Authors
Benedict, Christian
Sweden, Uppsala
Uppsala Universitet
Kilander, Lena
Sweden, Uppsala
Uppsala Universitet
Brooks, Samantha Jane
Sweden, Uppsala
Uppsala Universitet
Kullberg, Joel
Sweden, Uppsala
Uppsala Universitet
Larsson, Elna Marie
Sweden, Uppsala
Uppsala Universitet
Johansson, Lars O.M.
Sweden, Uppsala
Uppsala Universitet
Kempton, Matthew J.
United Kingdom, London
King's College London
Åhlström, Håkan K.
Sweden, Uppsala
Uppsala Universitet
Lind, Lars L.
Sweden, Uppsala
Uppsala Universitet
Schiöth, Helgi Birgir
Sweden, Uppsala
Uppsala Universitet
Statistics
Citations: 120
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.2337/dc11-2075
ISSN:
19355548
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female