Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
High incidences of DNA ploidy abnormalities in tongue squamous cell carcinoma of young patients: An international collaborative study
Histopathology, Volume 58, No. 7, Year 2011
Notification
URL copied to clipboard!
Description
Aims: This multi-centre analysis assessed the DNA content of TSCC in 37 young patients (<40years) and 28 old patients (>50years) and determined the correlation of DNA ploidy findings with clinicopathological data. Methods and results: Image cytometry was carried out using an automated cellular imaging system on Feulgen-stained histological sections to obtain high-fidelity DNA histograms. Among young patients, 37.8% were females compared to 18.7% in the older group (P=0.002). In total, 48.6% patients were non-smokers and 40.5% were non-drinkers compared to 10.7% non-smokers and non-drinkers in the older group (P<0.0001). TNM, clinical stage of disease and histological grade of differentiation did not differ between groups. Tumour aneuploidy was detected in 86.5% and tetraploidy in 24.3% young patients; this was significantly greater than in the older group where 64.3% were aneuploid (P<0.0001) and 7.2% tetraploid (P<0.0001). The mean values of DNA index (DI) and DNA heterogeneity index as well as the percentage of cells with DI exceeding 5N were higher in young patients (P<0.0001). Conclusions: Young patients with TSCC represent a distinct clinical entity. The high incidence of DNA ploidy abnormalities suggest that they may have increased genomic instability and indicates underlying genetic differences between TSCC in young and older patients. © 2011 Blackwell Publishing Limited.
Authors & Co-Authors
Santos-Silva, Alan Roger
Brazil, Campinas
Universidade Estadual de Campinas
Carlos-Bregni, Román
Guatemala, Guatemala City
Centro Clínico de Cabeza y Cuello
Speight, Paul M.
United Kingdom, Sheffield
The University of Sheffield
Hunter, Keith D.
United Kingdom, Sheffield
The University of Sheffield
Vargas, P. A.
Brazil, Campinas
Universidade Estadual de Campinas
Lopes, Márcio Ajudarte
Brazil, Campinas
Universidade Estadual de Campinas
Statistics
Citations: 50
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1111/j.1365-2559.2011.03863.x
ISSN:
13652559
Research Areas
Cancer
Genetics And Genomics
Study Design
Cohort Study
Participants Gender
Female