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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Q fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in Northern Tanzania
Clinical Infectious Diseases, Volume 53, No. 4, Year 2011
Notification
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Description
Background. The importance of Q fever, spotted fever group rickettsiosis (SFGR), and typhus group rickettsiosis (TGR) as causes of febrile illness in sub-Saharan Africa is unknown; the putative role of Q fever as a human immunodeficiency virus (HIV) coinfection is unclear. Methods. We identified febrile inpatients in Moshi, Tanzania, from September 2007 through August 2008 and collected acute-and convalescent-phase serum samples. A ≥4-fold increase in immunoglobulin (Ig) G immunfluorescence assay (IFA) titer to Coxiella burnetii phase II antigen defined acute Q fever. A ≥4-fold increase in IgG IFA titer to Rickettsia conorii or Rickettsia typhi antigen defined SFGR and TGR, respectively. Results. Among 870 patients, 483 (55.5%) were tested for acute Q fever, and 450 (51.7%) were tested for acute SFGR and TGR. Results suggested acute Q fever in 24 (5.0%) patients and SFGR and TGR in 36 (8.0%) and 2 (0.5%) patients, respectively. Acute Q fever was associated with hepato-or splenomegaly (odds ratio [OR], 3.1; P = .028), anemia (OR, 3.0; P = .009), leukopenia (OR, 3.9; P = .013), jaundice (OR, 7.1;P = .007), and onset during the dry season (OR, 2.7;P = .021). HIV infection was not associated with acute Q fever (OR, 1.7;P = .231). Acute SFGR was associated with leukopenia (OR, 4.1;P = .003) and with evidence of other zoonoses (OR, 2.2;P = .045) Conclusions. Despite being common causes of febrile illness in northern Tanzania, Q fever and SFGR are not diagnosed or managed with targeted antimicrobials. C. burnetii does not appear to be an HIV-associated coinfection. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Prabhu, Malavika
United States, Durham
Duke University Medical Center
Nicholson, William L.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Roche, Aubree J.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Kersh, Gilbert J.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Fitzpatrick, Kelly A.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Oliver, Lindsay D.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Massung, Robert F.
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
Morrissey, Anne B.
United States, Durham
Duke University Medical Center
Bartlett, John A.
United States, Durham
Duke University Medical Center
United States, Durham
Duke University
Onyango, Jecinta J.
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Maro, Venance Phillip
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Kinabo, Grace Damas
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Saganda, Wilbrod
Tanzania
Mawenzi Regional Hospital
Crump, John A.
United States, Durham
Duke University Medical Center
United States, Atlanta
Viral and Rickettsial Zoonoses Br.
United States, Durham
Duke University
Tanzania, Moshi
Kilimanjaro Christian Medical Centre
Tanzania, Moshi
Kilimanjaro Christian Medical University College
Statistics
Citations: 116
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1093/cid/cir411
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Infectious Diseases
Study Design
Case-Control Study
Study Locations
Tanzania