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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Early depletion of Mycobacterium tuberculosis - Specific T helper 1 cell responses after HIV-1 infection
Journal of Infectious Diseases, Volume 198, No. 11, Year 2008
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Description
Background. The acid-fast bacillus Mycobacterium tuberculosis is often the first manifestation of acquired immunodeficiency syndrome in patients infected with human immunodeficiency virus (HIV). This study was conducted to better understand the mechanism underlying M. tuberculosis-specific pathogenicity early after onset of HIV infection. Methods. M. tuberculosis-specific T helper 1 (Th1) cells were studied in HIV negative (n = 114) and chronically HIV infected (n = 68) Tanzanian subjects by using early secreted antigenic target 6 (ESAT6) protein or tuberculin (purified protein derivative) with interferon-γ ELISPOT and intracellular cytokine staining. In a longitudinal study, the effect of acute HIV infection on M. tuberculosis-specific Th1 cells was determined by polychromatic flow cytometric analysis in 5 subjects with latent M. tuberculosis infection who became infected with HIV. Results. In tuberculosis (TB)-asymptomatic subjects (i.e., subjects with unknown TB status who did not show clinical signs suggestive of TB), chronic HIV infection was associated with a decreased percentage of subjects with detectable M. tuberculosis-specific Th1 cells (P < .001), a decrease which was not observed among subjects with active TB. Acute HIV infection induced a rapid depletion of M. tuberculosis-specific Th1 cells in 4 subjects remained TB asymptomatic, whereas the population of these cells remained stable in subjects who remained HIV negative (P < .01). Conclusions. Taken together, these data suggest a mechanism of rapid M. tuberculosis-specific Th1 cell depletion that may contribute to the early onset of TB in individuals with latent M. tuberculosis infection who become HIV infected. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Geldmacher, Christof
United States, Bethesda
National Institutes of Health Nih
Germany, Munich
Klinikum Der Universität München
Schuetz, Alexandra
Tanzania, Tanga
National Institute for Medical Research Tanga
Tanzania, Mbeya
Mbeya Referral Hospital, Tanzania
Ngwenyama, Njabulo
United States, Bethesda
National Institutes of Health Nih
Casazza, Joseph P.
United States, Bethesda
National Institutes of Health Nih
Sanga, Erica Samson
Tanzania, Tanga
National Institute for Medical Research Tanga
Saathoff, Elmar
Germany, Munich
Klinikum Der Universität München
Boehme, Catharina C.
Germany, Munich
Klinikum Der Universität München
Switzerland, Geneva
Foundation for Innovative new Diagnostics, Switzerland
Geis, Steffen
Tanzania, Tanga
National Institute for Medical Research Tanga
Germany, Munich
Klinikum Der Universität München
Maboko, Leonard L.
Tanzania, Tanga
National Institute for Medical Research Tanga
Singh, Mahavir
Germany, Braunschweig
Lionex Diagnostics and Therapeutics Gmbh
Minja, Fred
Tanzania
National Tuberculosis and Leprosy Programme
Meyerhans, Andreas
Germany, Homburg
Universitätsklinikum Des Saarlandes Medizinische Fakultät Der Universität Des Saarlandes
Koup, Richard A.
United States, Bethesda
National Institutes of Health Nih
Höelscher, Michael
Germany, Munich
Klinikum Der Universität München
Statistics
Citations: 178
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1086/593017
ISSN:
00221899
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative