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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence of chronic kidney disease among people living with HIV/AIDS in Burundi: A cross-sectional study
BMC Nephrology, Volume 12, No. 1, Article 40, Year 2011
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Description
Background: Since little is known about chronic kidney disease (CKD) among people living with HIV/AIDS (PLWHA) in Sub-Saharan Africa, the prevalence and nature of CKD were assessed in Burundi through a multicenter cross-sectional study. Methods. Patients underwent assessments at baseline and 3 months later. Glomerular Filtration Rate (GFR) was estimated using abbreviated 4-variable Modification of Diet in Renal Diseases (MDRD) and Cockroft-Gault estimation methods. Patients were classified at month 3 into various CKD stages using the National Kidney Foundation (NKF) definition, which combines GFR and urinary abnormalities. Risk factors for presence of proteinuria (PRO) and aseptic leukocyturia (LEU) were further analyzed using multiple logistic regression. Results: Median age of the patients in the study (N = 300) was 40 years, 70.3% were female and 71.7% were on highly active antiretroviral therapy. Using the MDRD method, CKD prevalence in patients was 45.7%, 30.2% of whom being classified as stage 1 according to the NKF classification, 13.5% as stage 2 and 2% as stage 3. No patient was classified as stage 4 or 5. Among CKD patients with urinary abnormality, PRO accounted for 6.1% and LEU for 18.4%. Significant associations were found between LEU and non-steroidal anti-inflammatory drug (NSAID) use, previous history of tuberculosis, low body mass index and female gender and between PRO and high viral load. Conclusion: Our study, using a very sensitive definition for CKD evaluation, suggests a potentially high prevalence of CKD among PLWHA in Burundi. Patients should be regularly monitored and preventative measures implemented, such as monitoring NSAID use and adjustment of drug dosages according to body weight. Urine dipsticks could be used as a screening tool to detect patients at risk of renal impairment. © 2011 Cailhol et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Cailhol, Johann
France, Villetaneuse
University Sorbonne Paris Nord
Burundi
National Centre for Hiv Reference
Nkurunziza, Béatrice
Burundi
National Centre for Hiv Reference
Izzedine, Hassan
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Nindagiye, Emmanuel
Burundi
National Centre for Hiv Reference
Munyana, L.
Burundi
Bujumbura University Hospital
Baramperanye, Evelyne
Burundi
Association Nationale de Soutien Aux Séropositifs Anss
Nzorijana, Janvière
Burundi
Society of Women Against Aids (swaa)
Sakubu, Désiré
Unknown Affiliation
Niyongabo, Théodore
Burundi
National Centre for Hiv Reference
Burundi
Bujumbura University Hospital
Bouchaud, Olivier
France, Villetaneuse
University Sorbonne Paris Nord
Statistics
Citations: 57
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1186/1471-2369-12-40
e-ISSN:
14712369
Research Areas
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Burundi
Participants Gender
Female