Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Viridans group streptococcal infections in children after chemotherapy or stem cell transplantation: A 10-year review from a tertiary pediatric hospital
Medicine (United States), Volume 95, No. 9, Article e2952, Year 2016
Notification
URL copied to clipboard!
Description
Viridans Group Streptococci (VGS) are associated with high mortality rates in febrile neutropenia; yet there are no recent European pediatric studies to inform antimicrobial therapy. The aim of this study was to describe the characteristics, outcome, and resistance patterns of children with VGS bacteremia (VGSB) undergoing treatment of malignancy or hematopoietic stem cell transplant. Patients aged 0 to 18 years, admitted to a tertiary pediatric hematooncology center with VGSB, from 2003 to 2013, were included in the study. All data were collected retrospectively from medical records. A total of 54 bacteremic episodes occurred in 46 patients. The most common underlying diagnosis was relapsed acute lymphoblastic leukemia. Streptococcus mitis was the most frequent organism. A total of 30% of isolates were resistant to penicillin and 100% sensitive to vancomycin. There were 8 episodes (14.8%) of Viridans Group Streptococcal Shock Syndrome; 6 resulted in admission to intensive care and 3 of these patients died of multiorgan failure. The potentially fatal nature of VGSB is confirmed. The high risk in relapsed acute lymphoblastic leukemia is of note. Research is needed to develop risk-stratification scores that identify children at risk of Viridans Group Streptococcal Shock Syndrome to guide empirical antimicrobial therapy in febrile neutropenia. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Authors & Co-Authors
Nielsen, Maryke J.
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Pizer, Barry L.
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
United Kingdom, Liverpool
University of Liverpool
Lane, Steven
United Kingdom, Liverpool
University of Liverpool
Cooke, Richard P.D.
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Paulus, Stéphane C.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Carrol, Enitan D.
United Kingdom, Liverpool
University of Liverpool
United Kingdom, Liverpool
Alder Hey Children's Nhs Foundation Trust
Statistics
Citations: 18
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1097/MD.0000000000002952
ISSN:
00257974
Research Areas
Cancer
Health System And Policy
Maternal And Child Health