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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Extensively drug-resistant tuberculosis (XDR-TB) among health care workers in South Africa
Tropical Medicine and International Health, Volume 15, No. 10, Year 2010
Notification
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Description
OBJECTIVE: To determine the clinical profile and outcomes of health care workers (HCWs) with extensively drug resistant tuberculosis (XDR-TB) in the Eastern and Western Cape Provinces of South Africa. METHOD: Retrospective case record review of 334 patients with XDR-TB reported during the period 1996-2008 from Western and Eastern Cape Province, Cape Town, South Africa. Case records of HCWs with XDR-TB were analysed for clinical and microbiological features, and treatment outcomes. RESULTS: From 334 case records of patients with XDR-TB, 10 HCWs were identified. Eight of ten were HIV-uninfected, and four of 10 had died of XDR-TB despite treatment. All 10 HCWs had received an average of 2.4 courses of TB treatment before being diagnosed as XDR-TB. CONCLUSIONS: In the Eastern and Western Cape provinces of South Africa XDR-TB affects HCWs, is diagnosed rather late, does not appear to be related to HIV status and carries a high mortality. There is an urgent need for the South African government to implement WHO infection control recommendations and make available rapid drug susceptibility testing for HCWs with suspected multidrug-resistant (MDR)XDR-TB. Further studies to establish the actual risk and sources of infection (nosocomial or community) are required. © 2010 Blackwell Publishing Ltd.
Authors & Co-Authors
Jarand, Julie
Unknown Affiliation
Shean, Karen P.
Unknown Affiliation
O'Donnell, Max R.
Unknown Affiliation
Loveday, Marian
Unknown Affiliation
Kvasnovsky, Charlotte Louise
Unknown Affiliation
van der Walt, Martie L.
Unknown Affiliation
Adams, Shahieda
Unknown Affiliation
Willcox, Paul Anthony
Unknown Affiliation
O'Grady, Justin
Unknown Affiliation
Zumla, A. I.
Unknown Affiliation
Dheda, Keertan U.J.
Unknown Affiliation
Statistics
Citations: 43
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1111/j.1365-3156.2010.02590.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
South Africa