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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Hepatitis C virus NS5B sequence-based genotyping analysis of patients from the Sharkia governorate, Egypt
Hepatitis Monthly, Volume 13, No. 12, Article e12706, Year 2013
Notification
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Description
Background: Chronic hepatitis C virus infection and its sequela are major health problems facing the Egyptian community. The high prevalence and spread rates of the disease require serious actions to stop or decrease these rates. Determination of HCV genotypes and subgenotypes adds significant knowledge about the epidemiology of the disease, and provides an added value in the decision making process of what strategy to follow and what therapy response to expect. The molecular epidemiology and genetic variability of HCV variants circulating in Egypt still need further analysis. Objectives: The study was held to evaluate the genotype and subgenotype of the hepatitis c virus circulating in Sharkia as one of the large governorates of Egypt, which was not included in any study for genotyping of the virus before. Patients and Methods: The HCV molecular epidemiology in Sharkia governorate was studied using direct sequencing and further phylogenetic analysis of a partial NS5B region of the HCV genome from 63 patients. HCV genotype and subtype were successfully determined in 62 out of 63 patients. Results: The highest prevalent genotype was genotype 4a, which was found in 57 patients (92%) followed by 2 isolates (3%) with genotype 4o, 2 strains (3%) with genotype 1g and one isolate (2%) with genotype 4n. Conclusions: This molecular epidemiology study revealed high prevalence of HCV genotype 4, subtype 4a among Egyptian patients residing in Sharkia governorate, Egypt. © 2013, Kowsar Corp.
Authors & Co-Authors
Fakhr, Ahmed Elsadek
Belgium, Leuven
Rega Institute for Medical Research
Egypt, Zagazig
Zagazig University
Pourkarim, Mahmoud Reza
Belgium, Leuven
Rega Institute for Medical Research
Iran, Tehran
High Institute for Research and Education in Transfusion Medicine
Maes, Piet
Belgium, Leuven
Rega Institute for Medical Research
Atta, Amal Hassan M.
Egypt, Zagazig
Zagazig University
Marei, Ayman Mohamed
Egypt, Zagazig
Zagazig University
Azab, Magda
Egypt, Zagazig
Zagazig University
van Ranst, Marc A.
Belgium, Leuven
Rega Institute for Medical Research
Statistics
Citations: 18
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.5812/hepatmon.12706
ISSN:
1735143X
e-ISSN:
17353408
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Egypt