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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia
Naunyn-Schmiedeberg's Archives of Pharmacology, Volume 377, No. 1, Year 2008
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Description
In this study, we examined the effects of systemic and local administration of the subtype-selective adenosine receptor antagonists PSB-36, PSB-1115, MSX-3, and PSB-10 on inflammation and inflammatory hyperalgesia. Pharmacological blockade of adenosine receptor subtypes after systemic application of antagonists generally led to a decreased edema formation after formalin injection and, with the exception of A3 receptor antagonism, also after the carrageenan injection. The selective A2B receptor antagonist PSB-1115 showed a biphasic, dose-dependent effect in the carrageenan test, increasing edema formation at lower doses and reducing it at a high dose. A1 and A2B antagonists diminished pain-related behaviors in the first phase of the formalin test, while the second, inflammatory phase was attenuated by A2B and A3 antagonists. The A 2B antagonist was particularly potent in reducing inflammatory pain dose-dependently reaching the maximum effect at a low dose of 3 mg/kg. Inflammatory hyperalgesia was totally eliminated by the A2A antagonist MSX-3 at a dose of 10 mg/kg. In contrast to the A1 antagonist, the selective antagonists of A2A, A2B, and A3 receptors were also active upon local administration. Our results demonstrate that the blockade of adenosine receptor subtypes can decrease the magnitude of inflammatory responses. Selective A2A antagonists may be useful for the treatment of inflammatory hyperalgesia, while A2B antagonists have potential as analgesic drugs for the treatment of inflammatory pain. © 2007 Springer-Verlag.
Authors & Co-Authors
Bilkei-Gorzó, András
Germany, Bonn
Universität Bonn
Abo-Salem, Osama Mohamed
Germany, Bonn
Universität Bonn
Egypt, Cairo
Al-azhar University
Hayallah, Alaa M.
Germany, Bonn
Universität Bonn
Egypt, Asyut
Faculty of Pharmacy
Michel, Kerstin
Germany, Bonn
Universität Bonn
Müller, Christa Elisabeth
Germany, Bonn
Universität Bonn
Zimmer, Andreas M.
Germany, Bonn
Universität Bonn
Statistics
Citations: 47
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1007/s00210-007-0252-9
ISSN:
00281298