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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High rate of hypothyroidism among patients treated for multidrug-resistant tuberculosis in Lesotho
International Journal of Tuberculosis and Lung Disease, Volume 16, No. 4, Year 2012
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Description
BACKGROUND: Hypothyroidism is a known side effect of treatment for multidrug-resistant tuberculosis (MDRTB), but it is considered to be rare. Hypothyroidism has vague and non-specific symptoms, and can be easily missed by clinicians. OBJECTIVE: To report the high rate of hypothyroidism in a cohort of MDR-TB patients in Lesotho and to describe our approach to diagnosis and management. DESIGN: A retrospective study of 212 patients who initiated treatment for MDR-TB in Lesotho between 27 July 2007 and 24 March 2009 was performed. RESULTS: Among 186 patients screened, 129 (69%) had hypothyroidism, defined as at least one documented thyroid-stimulating hormone (TSH) result > 10.0 mIU/l; 100 (54%) patients had a maximum TSH > 20.0 mIU/l. At 93 days after starting MDR-TB treatment, half of the patients had developed hypothyroidism. CONCLUSION: Hypothyroidism may be more common during MDR-TB treatment than previously recognized. Screening all patients, even those without symptoms, for hypothyroidism within 2-3 months of starting MDRTB treatment should be considered until prospective studies can inform screening guidelines. © 2012 The Union.
Authors & Co-Authors
Satti, Hind
United States, Boston
Partners in Health
United States, Boston
Harvard Medical School
Mafukidze, Arnold T.
United States, Boston
Partners in Health
Jooste, Pieter L.
South Africa, Tygerberg
South African Medical Research Council
McLaughlin, Megan M.
United States, Boston
Brigham and Women's Hospital
Farmer, Paul E.
United States, Boston
Harvard Medical School
United States, Boston
Brigham and Women's Hospital
United States, Boston
Partners in Health
Seung, Kwonjune J.
United States, Boston
Partners in Health
United States, Boston
Brigham and Women's Hospital
Statistics
Citations: 44
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.5588/ijtld.11.0615
ISSN:
10273719
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
Lesotho