Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Heart failure due to 'stress cardiomyopathy': A severe manifestation of the opioid withdrawal syndrome
European Heart Journal: Acute Cardiovascular Care, Volume 2, No. 1, Year 2013
Notification
URL copied to clipboard!
Description
Takotsubo cardiomyopathy (TTC) is a transient left ventricular (LV) dysfunction due to akinesia of the LV mid-apical segments ('apical ballooning') in the absence of critical coronary stenoses which can be complicated in the acute phase by heart failure, mitral regurgitation, life-threatening ventricular arrhythmias, or apical LV thrombosis. The syndrome is typically precipitated by intense emotional or physical stress; however, other causes of sympathetic overstimulation including administration of exogenous sympathomimetics or withdrawal of sympathetic antagonists can trigger TTC. We report the case of a patient who unexpectedly developed an 'apical ballooning' with severe reduction in the LV systolic function and heart failure after the withdrawal of methadone. The case supports the concept that increased sympathetic activity secondary to opioids withdrawal can trigger a stress-induced severe LV dysfunction. Physicians should be aware that the abrupt discontinuation of a long-term therapy with opioids may lead to serious cardiac complications. The administration of clonidine may be considered to prevent early clinical manifestations of addictive withdrawal, including TTC. © 2013 The European Society of Cardiology.
Authors & Co-Authors
Spadotto, Veronica
Italy, Padua
Università Degli Studi Di Padova
Alessandro, Zorzi
Italy, Padua
Università Degli Studi Di Padova
ElMaghawry, Mohamed
Italy, Padua
Università Degli Studi Di Padova
Egypt, Aswan
Aswan Heart Center
Meggiolaro, Marco
Italy, Padua
Azienda Ospedale Università Padova
Pittoni, Giovanni Maria
Italy, Padua
Azienda Ospedale Università Padova
Statistics
Citations: 36
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1177/2048872612474923
ISSN:
20488726
e-ISSN:
20488734
Research Areas
Health System And Policy
Noncommunicable Diseases