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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Nature Genetics, Volume 45, No. 10, Year 2013
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Description
Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other crowd diseases, the origin of human tuberculosis has been associated with the Neolithic Demographic Transition, but recent studies point to a much earlier origin. We analyzed the whole genomes of 259 M. Tuberculosis complex (MTBC) strains and used this data set to characterize global diversity and to reconstruct the evolutionary history of this pathogen. Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period. This long coevolutionary history is consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities. © 2013 Nature America, Inc. All rights reserved.
Authors & Co-Authors
Comas, Iñaki T.
Spain, Valencia
Centre for Public Health Research Csisp
Spain, Madrid
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Coscollá, Mireia
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Luo, Tao
China, Beijing
Ministry of Education of the People's Republic of China
Borrell, Sònia
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Holt, Kathryn E.
Australia, Melbourne
University of Melbourne
Australia, Melbourne
Bio21 Molecular Science and Biotechnology Institute
Kato-Maeda, Midori
United States, San Francisco
University of California, San Francisco
Parkhill, Julian
United Kingdom, Hinxton
Wellcome Sanger Institute
Malla, Bijaya
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Berg, Stefan
United Kingdom, Addlestone
Animal and Plant Health Agency
Thwaites, G. E.
United Kingdom, London
King's College London
Yeboah-Manu, Dorothy
Ghana, Accra
Noguchi Memorial Institute for Medical Research
Bothamley, Graham Henry
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Mei, Jian
China, Shanghai
Shanghai Municipal Center for Disease Control and Prevention
Wei, Lanhai
China, Shanghai
Fudan University
Bentley, Stephen D.
United Kingdom, Hinxton
Wellcome Sanger Institute
Harris, Simon R.
United Kingdom, Hinxton
Wellcome Sanger Institute
Niemann, Stefan
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Diel, Roland
Germany, Kiel
Universitätsklinikum Schleswig-holstein Campus Kiel
Aseffa, Abraham
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
United Kingdom, London
Imperial College London
Gao, Qian
China, Beijing
Ministry of Education of the People's Republic of China
Young, Douglas Brownlee
United Kingdom, London
Mrc National Institute for Medical Research
United Kingdom, London
Imperial College London
Gagneux, Sébastien P.
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Switzerland, Basel
Universitat Basel
Statistics
Citations: 909
Authors: 22
Affiliations: 20
Identifiers
Doi:
10.1038/ng.2744
ISSN:
10614036
e-ISSN:
15461718
Study Design
Cross Sectional Study