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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Vasopressin and galanin expression in the hypothalamus of two African rodents, Taterillus gracilis and Steatomys caurinus, subjected to water-restriction
General and Comparative Endocrinology, Volume 133, No. 1, Year 2003
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Description
The expression of arginine-vasopressin (AVP) and galanin (GAL) was studied by immunohistochemistry and in situ hybridization in the hypothalamus of two species of African rodents. In the wild, these animals experience successive arid and wet seasons that alternately stimulate their antidiuretic and diuretic systems. In this study, animals were subjected to both standardized laboratory conditions and to eight days of water-restriction. Under both sets of conditions, AVP and GAL were detected in the supraoptic nucleus (SON), paraventricular nucleus (PVN), and median eminence (ME). AVP and GAL responses to water-restriction differed in the two species, as did behavioral adaptations to the hot-dry season. In Taterillus gracilis, AVP- and GAL-LI (like immunoreactivity) peptide and mRNA levels increased in the SON. AVP-LI peptide and mRNA levels increased in the PVN, whereas only AVP-LI peptide levels increased in the ME. Pituitary gland AVP pools were unchanged by water deprivation, whereas urinary AVP levels and osmolality increased. The AVP response is typical of that of desert rodents, favoring survival under conditions of water-restriction. In Steatomys caurinus, which estivates, AVP and GAL-LI peptide levels decreased in the hypothalamus, as they did in the laboratory rat. In the SON, AVP, and GAL mRNA levels increased, whereas, in the PVN, only AVP mRNA levels increased. Pituitary gland AVP levels decreased, whereas urinary AVP levels and osmolality increased. In both species, the changes in the amount of GAL-LI peptide appeared to be closely linked to changes in AVP levels, suggesting that this peptide is involved in the osmoregulatory response to water-restriction. © 2003 Elsevier Science (USA). All rights reserved.
Authors & Co-Authors
Lacas-Gervais, Sandra
France, Paris
Cnrs Centre National de la Recherche Scientifique
Maurel, Daniel L.
France, Paris
Inserm
Hubert, F.
France, Montpellier
Centre de Recherche en Biologie Cellulaire de Montpellier
Allevard, A. M.
France, Villeurbanne
Université Claude Bernard Lyon 1
Doukary, A.
Mali, Bamako
Institut de Recherche Pour le Developpement Mali
Maggi, V.
France, Villeurbanne
Université Claude Bernard Lyon 1
Siaud, Philippe
France, Paris
Inserm
Gharib, Claude
France, Villeurbanne
Université Claude Bernard Lyon 1
Sicard, Bruno
Mali, Bamako
Institut de Recherche Pour le Developpement Mali
France, Montferrier-sur-lez
Centre de Biologie Pour la Gestion Des Populations Cbgp
Calas, André Guilhem
France, Paris
Cnrs Centre National de la Recherche Scientifique
Hardin-Pouzet, Hélène
France, Paris
Cnrs Centre National de la Recherche Scientifique
Statistics
Citations: 11
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1016/S0016-6480(03)00161-8
Research Areas
Environmental
Genetics And Genomics