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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques
PLoS ONE, Volume 13, No. 8, Article e0202997, Year 2018
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Description
HIV mutates rapidly and infects CD4+ T cells, especially when they are activated. A vaccine targeting conserved, essential viral elements while limiting CD4+ T cell activation could be effective. Learning from natural immunity observed in a group of highly HIV-1 exposed seronegative Kenyan female sex workers, we are testing a novel candidate HIV vaccine targeting the 12 viral protease cleavage sites (PCSs) (the PCS vaccine), in comparison with a vaccine targeting full-length Gag and Env (the Gag/Env vaccine) in a Mauritian cynomolgus macaque/SIV model. In this study we evaluated these vaccines for induction of mucosal antibodies to SIV immunogens at the female genital tract. Bio-Plex and Western blot analyses of cervicovaginal lavage samples showed that both the PCS and Gag/Env vaccines can elicit mucosal IgG antibody responses to SIV immunogens. Significantly higher increase of anti-PCS antibodies was induced by the PCS vaccine than by the Gag/Env vaccine (p<0.0001). The effect of the mucosal antibody responses in protection from repeated low dose pathogenic SIVmac251 challenges is being evaluated. © 2018 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Authors & Co-Authors
Lim, Soyon
United States, Boston
Beth Israel Deaconess Medical Center
Li, Lin
Canada, Ottawa
Public Health Agency of Canada
Omange, Robert Were
Canada, Winnipeg
University of Manitoba
Kashem, Mohammad Abul
Canada, Winnipeg
University of Manitoba
Liang, Binhua B.
Canada, Ottawa
Public Health Agency of Canada
Canada, Winnipeg
University of Manitoba
Li, Qingsheng
United States, Lincoln
University of Nebraska–lincoln
Rakasz, Eva G.
United States, Madison
Wisconsin National Primate Research Center
Alonso Fernández, María José
Spain, Santiago de Compostela
Universidad de Santiago de Compostela
Plummer, Francis Allan
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Whitney, James B.
United States, Boston
Beth Israel Deaconess Medical Center
United States, Cambridge
Massachusetts Institute of Technology
Luo, Ma
Canada, Winnipeg
University of Manitoba
Canada, Ottawa
Public Health Agency of Canada
Statistics
Citations: 10
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1371/journal.pone.0202997
ISSN:
19326203
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Female