Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The epidemiology of conjunctival squamous cell carcinoma in Uganda
British Journal of Cancer, Volume 87, No. 3, Year 2002
Notification
URL copied to clipboard!
Description
As part of a larger investigation of cancer in Uganda, we conducted a case-control study of conjunctival squamous cell carcinoma in adults presenting at hospitals in Kampala. Participants were interviewed about social and lifestyle factors and had blood tested for antibodies to HIV, KSHV and HPV-16, -18 and -45. The odds of each factor among 60 people with conjunctival cancer was compared to that among 1214 controls with other cancer sites or types, using odds ratios, estimated with unconditional logistic regression. Conjunctival cancer was associated with HIV infection (OR 10.1, 95% confidence intervals [CI] 5.2-19.4; P < 0.001), and was less common in those with a higher personal income (OR 0.4, 95% CI 0.3-1.2; P < 0.001). The risk of conjunctival cancer increased with increasing time spent in cultivation and therefore in direct sunlight (X2 trend=3.9, P=0.05), but decreased with decreasing age at leaving home (X2 trend=3.9, P=0.05), perhaps reflecting less exposure to sunlight consequent to working in towns, although both results were of borderline statistical significance. To reduce confounding, sexual and reproductive variables were examined among HIV seropositive individuals only. Cases were more likely than controls to report that they had given or received gifts for sex (OR 3.5, 95% CI 1.2-10.4; P=0.03), but this may have been a chance finding as no other sexual or reproductive variable was associated with conjunctival cancer, including the number of self-reported lifetime sexual partners (P=0.4). The seroprevalence of antibodies against HPV-18 and -45 was too low to make reliable conclusions. The presence of anti-HPV-16 antibodies was not significantly associated with squamous cell carcinoma of the conjunctiva (OR 1.5, 95% CI 0.5-4.3; P=0.5) and nor were anti-KSHV antibodies (OR 0.9, 95% CI 0.4-2.1; P=0.8). The 10-fold increased risk of conjunctival cancer in HIV infected individuals is similar to results from other studies. The role of other oncogenic viral infections is unclear. © 2002 Cancer Research UK.
Authors & Co-Authors
Newton, Robert A.
United Kingdom, London
Cancer Research uk
Ziegler, John L.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Ateenyi-Agaba, Charles
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Bousarghin, Latifa
France, Paris
Inserm
Casabonne, Delphine
United Kingdom, London
Cancer Research uk
Beral, Valerie
United Kingdom, London
Cancer Research uk
Mbidde, Edward Katongole
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Carpenter, Lucy J.
Uganda, Entebbe
Uganda Virus Research Institute
Reeves, Gillian K.
United Kingdom, London
Cancer Research uk
Parkin, Donald Maxwell
France, Lyon
Centre International de Recherche Sur le Cancer
Wabinga, Henry R.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Mbulaiteye, Sam M.
Uganda, Kampala
School of Medicine, Makerere University College of Health Sciences
Jaffe, Harold W.
United States, Atlanta
Centers for Disease Control and Prevention
Bourboulia, Dimitra
United Kingdom, London
Barts and the London School of Medicine and Dentistry
Boshoff, Chris H.
United Kingdom, London
Cancer Research uk
Touzé, Antoine
France, Paris
Inserm
Coursaget, Pierre L.
France, Paris
Inserm
Rwatooro, C.
Unknown Affiliation
Nambooze, Sarah
Unknown Affiliation
Tushimiere, B.
Unknown Affiliation
Byabazaire, Naome
Unknown Affiliation
Bitamazire, E.
Unknown Affiliation
Katabira, Elly Tebasoboke
Unknown Affiliation
Mugerwa, Joshua W.
Unknown Affiliation
Tindyebura, D.
Unknown Affiliation
Whitworth, James Ag
Unknown Affiliation
Richardson, Brian Douglas
Unknown Affiliation
Weiss, Robin A.
Unknown Affiliation
de Cock, Kevin M.
Unknown Affiliation
Statistics
Citations: 113
Authors: 29
Affiliations: 7
Identifiers
Doi:
10.1038/sj.bjc.6600451
Research Areas
Cancer
Infectious Diseases
Sexual And Reproductive Health
Study Design
Case-Control Study
Study Locations
Uganda