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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: An international study
Clinical and Experimental Allergy, Volume 38, No. 1, Year 2008
Notification
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Description
Background: Studies of Australian infants have reported that more than 80% of those with moderate atopic eczema (AE) have high levels of IgE food sensitization (IgE-FS) that are commonly associated with IgE food allergy. Objectives: To explore the relationship between high levels of IgE-FS and AE in a large cohort of young children with eczema participating in a multi-centre, international study. Methods: Two thousand one hundred and eighty-four subjects (mean age 17.6 months, range 11.8-25.4; 1246 males) with active eczema from atopic families from 94 centres in 12 countries were studied. Clinical history, Scoring Atopic Dermatitis index as a measure of eczema severity and CAP-FEIA measurements for total IgE and IgE antibody levels to cow milk, egg and peanut were entered into a database. If CAP-FEIA levels exceeded previously reported age-specific cut-off levels for 95% positive predictive values (PPVs) for food allergy, subjects were defined as having high-risk IgE-FS (HR-IgE-FS). Results: Serum was available from 2048 patients; 55.5% were atopic. The frequency of HR-IgE-FS to milk, egg and/or peanut was the greatest in patients whose eczema developed in the first 3 months of life and the least in those whose eczema developed after 12 months (P<0.0001). In a regression analysis to allow for potential confounding factors, children with HR-IgE-FS had the most severe eczema and the youngest age of onset (P<0.001); 64% of infants with severe eczema of onset-age <3 months had HR-IgE-FS. Conclusion: Early-onset severe eczema in infancy was associated with HR-IgE-FS. Clinical implications: Food allergies should be routinely assessed in infants with moderate or severe eczema. Capsule summary: In eczematous infants, the earlier the age of onset, and the greater the severity of eczema, the greater the frequency of associated high levels of IgE-FS. © 2007 Blackwell Publishing Ltd.
Authors & Co-Authors
de Benedictis, Fernando Maria D.
Unknown Affiliation
Oranje, Arnold P.
Netherlands, Rotterdam
Erasmus Mc
Diepgen, Thomas Ludwig
Unknown Affiliation
Warner, John Oliver
Unknown Affiliation
Naspitz, Charles Kirov
Unknown Affiliation
Simons, F. E.R.
Unknown Affiliation
Wahn, Ulrich
Unknown Affiliation
von Mutius, Erika R.M.
Unknown Affiliation
Gold, Michael Steven
Unknown Affiliation
Marshall, Helen Siobhan
Unknown Affiliation
Sly, Peter D.
Unknown Affiliation
Loh, Richard K.S.
Unknown Affiliation
Halbert, Anne R.
Unknown Affiliation
Stick, S. M.
Unknown Affiliation
van Asperen, Peter Paul
Unknown Affiliation
Škopková, Olga
Unknown Affiliation
Petrů, Vít
Unknown Affiliation
Pohunek, Petr
Unknown Affiliation
Cambazard, Frederique É.
Unknown Affiliation
Rancé, Fabienne
Unknown Affiliation
Niggemann, Bodo
Unknown Affiliation
Schauer, Uwe
Unknown Affiliation
Hertl, Michael S.
Unknown Affiliation
Ring, Johannes
Unknown Affiliation
von Berg, Andrea
Unknown Affiliation
Albrecht, Beate
Unknown Affiliation
Duse, Marzia
Unknown Affiliation
Fiocchi, Alessandro Giovanni
Unknown Affiliation
Terracciano, L. Maria
Unknown Affiliation
Marseglia, Gian Luigi
Unknown Affiliation
Tzialla, Chryssoula
Unknown Affiliation
Galli, E.
Unknown Affiliation
Rossi, Paolo
Unknown Affiliation
Moschese, Viviana
Unknown Affiliation
Boner, Attillio Loris
Unknown Affiliation
Pasmans, S. G.M.A.
Unknown Affiliation
Lis, Grzegorz J.
Unknown Affiliation
Emeryk, Andrzej
Unknown Affiliation
Brȩborowicz, Anna
Unknown Affiliation
Kulus, Marek Krzysztof
Unknown Affiliation
Boznánski, Andrzej
Unknown Affiliation
Asensio-De-La-Cruz, Òscar
Unknown Affiliation
Nieto García, Antonio
Unknown Affiliation
Puterman, Allan S.
Unknown Affiliation
Vermeulen, Jan H.
Unknown Affiliation
Suleman, Moosa
Unknown Affiliation
Potter, Paul C.
Unknown Affiliation
Hawarden, D.
Unknown Affiliation
Motala, Cassim M.
Unknown Affiliation
Weber, Heinrich C.
Unknown Affiliation
Reyneke, S. J.
Unknown Affiliation
Morison, Adrian
Unknown Affiliation
Arshad, Syed Hasan
Unknown Affiliation
Roberts, Graham C.
Unknown Affiliation
Hourihane, Jonathan O.Brien
Unknown Affiliation
Roberts, Graham C.
Unknown Affiliation
Statistics
Citations: 186
Authors: 56
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-2222.2007.02861.x
ISSN:
13652222
Research Areas
Food Security
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative