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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Treatment of Wilms tumor according to SIOP 9 protocol in Casablanca, Morocco
Pediatric Blood and Cancer, Volume 46, No. 4, Year 2006
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Description
Background. Childhood Wilms tumor represents one of the challenge for pediatric oncologists in developing countries. We report the characteristics and treatment results of patients with Wilms tumor according to SIOP 9 protocol in Morocco. Procedure. From January 1989 to December 2000, 86 children with Wilms tumor were admitted. The diagnosis was based on physical exam and abdominal ultrasound. The metastatic work-up was based on abdominal ultrasound and chest X-ray. Results. The mean age was 36 months (3-120 months). The sex-ratio was 1. Abdominal mass was the main symptom at presentation (84 cases). There were 13 metastatic cases. Treatment applied was according to SIOP 9 Protocol without randomization. Local deases of was present in 75 patients with stage I in 38 cases (50%), IIN0 in 4 cases (6%), IIN1 in 9 cases, and III in 24 cases (44%). The distribution of pathologic groups was: favorable in 4 cases, standard in 69 cases, and unfavorable anaplastic type in 2 cases. Sixty-nine patients were evaluable for therapeutic evaluation. Other patients were lost to follow-up. Three patients died of treatment related toxicity and 13 patients relapsed. With a median follow-up of 70 months, the 5-year EFS and 5 years overall survival for evaluable patients are 77.4% and 79%, respectively while the 5-year EFS for all patients was 56%. Conclusion. These results are encouraging for a developing country but special efforts should be done to reduce the rate of abandonment. © 2005 Wiley-Liss, Inc.
Authors & Co-Authors
Madani, Abdellah
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Zafad, Saadia
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Harif, M'hamed
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Yaakoubi, Mohammed
Morocco, Agdal Rabat
Hôpital D'enfants
Zamiati, Soumaya
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Sahraoui, Souha
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Benjelloun, Amal
Morocco, Agdal Rabat
Hôpital D'enfants
Fehri, Mohammed
Morocco, Agdal Rabat
Hôpital D'enfants
Benchekroun, Saïd
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Statistics
Citations: 57
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1002/pbc.20436
ISSN:
15455009
e-ISSN:
15455017
Research Areas
Cancer
Maternal And Child Health
Study Design
Randomised Control Trial
Cohort Study
Study Locations
Morocco