Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
Nature, Volume 596, No. 7872, Year 2021
Notification
URL copied to clipboard!
Description
Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age1. Here we analysed immune responses following vaccination with the BNT162b2 mRNA vaccine2 in elderly participants and younger healthcare workers. Serum neutralization and levels of binding IgG or IgA after the first vaccine dose were lower in older individuals, with a marked drop in participants over eighty years old. Sera from participants above eighty showed lower neutralization potency against the B.1.1.7 (Alpha), B.1.351 (Beta) and P.1. (Gamma) VOC than against the wild-type virus and were more likely to lack any neutralization against VOC following the first dose. However, following the second dose, neutralization against VOC was detectable regardless of age. The frequency of SARS-CoV-2 spike-specific memory B cells was higher in elderly responders (whose serum showed neutralization activity) than in non-responders after the first dose. Elderly participants showed a clear reduction in somatic hypermutation of class-switched cells. The production of interferon-γ and interleukin-2 by SARS-CoV-2 spike-specific T cells was lower in older participants, and both cytokines were secreted primarily by CD4 T cells. We conclude that the elderly are a high-risk population and that specific measures to boost vaccine responses in this population are warranted, particularly where variants of concern are circulating. © 2021, The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8373615/bin/41586_2021_3739_MOESM1_ESM.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC8373615/bin/41586_2021_3739_MOESM2_ESM.pdf
Authors & Co-Authors
Collier, Dami Aderonke
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Ferreira, Isabella A.T.M.
United Kingdom, Cambridge
University of Cambridge
Datir, Rawlings P.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Meng, Bo
United Kingdom, Cambridge
University of Cambridge
Abdullahi, Adam
Unknown Affiliation
Baker, Stephen G.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Dougan, Gordon J.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Hess, Christoph
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Switzerland, Basel
Universitätsspital Basel
Kingston, Nathalie
United Kingdom, Cambridge
University of Cambridge
Lehner, P. Joseph
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Lyons, Paul A.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Matheson, Nicholas J.
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Saunders, Caroline
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Summers, Charlotte
United Kingdom, London
University College London
United Kingdom, Cambridge
Royal Papworth Hospital Nhs Foundation Trust
United Kingdom, Cambridge
Addenbrooke's Hospital
Toshner, Mark R.
United Kingdom, London
University College London
United Kingdom, Cambridge
Royal Papworth Hospital Nhs Foundation Trust
Weekes, Michael P.
United Kingdom, Cambridge
University of Cambridge
Shaw, Ashley S.
United Kingdom, Cambridge
Addenbrooke's Hospital
Bucke, Ashlea
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Calder, Jo
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Canna, Laura
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Domingo, Jason
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Elmer, Anne
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Harris, Julie
United Kingdom, London
Cancer Research uk
Hewitt, Sarah
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Kennet, Jane
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Jose, Sherly
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Kourampa, Jenny
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Meadows, Anne
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Price, Jane
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Rastall, Rebecca J.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Ribeiro, Carla G.
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Rowlands, Jane
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Tordesillas, Hugo
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Dunmore, Benjamin J.
United Kingdom, London
University College London
Huang, Christopher L.H.
United Kingdom, London
University College London
Mescia, Federica
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Bergamaschi, Laura
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Gleadall, Nicholas S.
United Kingdom, Cambridge
University of Cambridge
Huhn, Oisín
United Kingdom, Cambridge
Rosie Hospital
Jarvis, Isobel
United Kingdom, London
University College London
Stephens, Jonathan Claiborne
United Kingdom, Cambridge
University of Cambridge
Turner, Lori
United Kingdom, Cambridge
University of Cambridge
United Kingdom, London
University College London
Holmes, E. C.
Australia, Perth
Murdoch University
Dewhurst, Eleanor F.
United Kingdom, Cambridge
University of Cambridge
Papadia, Sofia
United Kingdom, Cambridge
University of Cambridge
Stirrups, Kathleen E.
Unknown Affiliation
Townsend, Paul A.
Unknown Affiliation
Smith, Kenneth G.C.
United Kingdom, Cambridge
University of Cambridge
Ceron-Gutierrez, Lourdes
United Kingdom, Cambridge
Addenbrooke's Hospital
Barcenas-Morales, Gabriela
Mexico, Mexico
Universidad Nacional Autónoma de México
Linterman, Michelle A.
United Kingdom, Cambridge
The Babraham Institute
McCoy, Laura E.
United Kingdom, London
University College London
Davis, Christopher A.
United Kingdom, Glasgow
Mrc-university of Glasgow Centre for Virus Research
Thomson, Emma C.
United Kingdom, Glasgow
Mrc-university of Glasgow Centre for Virus Research
Döffinger, Rainer
United Kingdom, Cambridge
University of Cambridge
Wills, Mark R.
United Kingdom, Cambridge
University of Cambridge
Gupta, Ravindra K.
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 393
Authors: 57
Affiliations: 15
Identifiers
Doi:
10.1038/s41586-021-03739-1
ISSN:
00280836
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study