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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal cancer prevention
Molecular Nutrition and Food Research, Volume 57, No. 11, Year 2013
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Description
Scope: Anthocyanins, the natural pigments in plant foods, have been associated with cancer prevention. However, the content of anthocyanins in staple foods is typically low and the mechanisms by which they exert anticancer activity is not yet fully defined. Methods and results: We selected an anthocyanin-enriched purple-fleshed sweet potato clone, P40, and investigated its potential anticancer effect in both in vitro cell culture and in vivo animal model. In addition to a high level of total phenolics and antioxidant capacity, P40 possesses a high content of anthocyanins at 7.5 mg/g dry matter. Treatment of human colonic SW480 cancer cells with P40 anthocyanin extracts at 0-40 μM of peonidin-3-glucoside equivalent resulted in a dose-dependent decrease in cell number due to cytostatic arrest of cell cycle at G1 phase but not cytotoxicity. Furthermore, dietary P40 at 10-30% significantly suppressed azoxymethane-induced formation of aberrant crypt foci in the colons of CF-1 mice in conjunction with, at least in part, a lesser proliferative PCNA and a greater apoptotic caspase-3 expression in the colon mucosal epithelial cells. Conclusion: These observations, coupled with both in vitro and in vivo studies reported here, suggest anthocyanin-enriched sweet potato P40 may protect against colorectal cancer by inducing cell-cycle arrest, antiproliferative, and apoptotic mechanisms. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Lim, Soyoung
United States, Manhattan
Kansas State University
Xu, Jianteng
United States, Manhattan
Kansas State University
Kim, Jaeyong
United States, Manhattan
Kansas State University
Chen, Tzu Yu
United States, Manhattan
Kansas State University
Su, Xiaoyu
United States, Manhattan
Kansas State University
Standard, Joseph
United States, Manhattan
Kansas State University
Carey, Edward Ewing
Ghana, Kumasi
International Potato Center
Griffin, Jason J.
United States, Manhattan
Kansas State University
Herndon, Betty
United States, Kansas City
University of Missouri-kansas City
Katz, Benjamin
United States, Manhattan
Kansas State University
Tomich, John
United States, Manhattan
Kansas State University
Wang, Weiqun
United States, Manhattan
Kansas State University
Statistics
Citations: 157
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1002/mnfr.201300040
ISSN:
16134125
e-ISSN:
16134133
Research Areas
Cancer