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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms
Molecular Systems Biology, Volume 17, No. 10, Article e10387, Year 2021
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Description
We need to effectively combine the knowledge from surging literature with complex datasets to propose mechanistic models of SARS-CoV-2 infection, improving data interpretation and predicting key targets of intervention. Here, we describe a large-scale community effort to build an open access, interoperable and computable repository of COVID-19 molecular mechanisms. The COVID-19 Disease Map (C19DMap) is a graphical, interactive representation of disease-relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph-based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. This framework helps to find signatures of SARS-CoV-2 predisposition, treatment response or prioritisation of drug candidates. Such an approach may help deal with new waves of COVID-19 or similar pandemics in the long-term perspective. © 2021 The Authors. Published under the terms of the CC BY 4.0 license
Authors & Co-Authors
Ostaszewski, Marek
Luxembourg, Esch-sur-alzette
University of Luxembourg
Acencio, Marcio Luis
Luxembourg, Esch-sur-alzette
University of Luxembourg
Glaab, Enrico
Luxembourg, Esch-sur-alzette
University of Luxembourg
Hoch, Matti
Germany, Rostock
Universität Rostock
Funahashi, Akira
Japan, Tokyo
Keio University
Dräger, Andreas
Germany, Tubingen
Eberhard Karls Universität Tübingen
Germany, Tubingen
Partner Site Tübingen
Messina, Francesco
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Ehrhart, Friederike
Netherlands, Maastricht
Universiteit Maastricht
Rex, Devasahayam Arokia Balaya
India, Mangalore
Yenepoya Deemed to be University
Martens, Marvin
Netherlands, Maastricht
Universiteit Maastricht
Fraser, Rupsha
United Kingdom, Edinburgh
The University of Edinburgh
Ortseifen, Vera
Germany, Bielefeld
Universität Bielefeld
Satagopam, Venkata Pardhasaradhi
Luxembourg, Esch-sur-alzette
University of Luxembourg
Golebiewski, Martin
Germany, Heidelberg
Heidelberg Institute for Theoretical Studies Hits Gmbh
Owen, Stuart
United Kingdom, Manchester
The University of Manchester
Goble, Carole Anne
United Kingdom, Manchester
The University of Manchester
Maier, Dieter
Unknown Affiliation
Yuryev, Anton
Netherlands, Amsterdam
Elsevier B.v.
Esteban-Medina, Marina
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Peña-Chilet, María
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Rian, Kinza
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Módos, Dezső
United Kingdom, Norwich
Quadram Institute Bioscience
United Kingdom, Norwich
Earlham Institute
De-Meulder, Bertrand
Unknown Affiliation
Naldi, Aurélien
France, Palaiseau
Inria Saclay
Calzone, Laurence
France, Paris
Institut Curie
France, Paris
Inserm
France, Paris
Université Psl
Korcsmáros, Tamás
United Kingdom, Norwich
Quadram Institute Bioscience
United Kingdom, Norwich
Earlham Institute
Freeman, Tom C.
United Kingdom, Edinburgh
The University of Edinburgh
Beckmann, Jacques S.
Switzerland, Lausanne
Université de Lausanne Unil
Hasenauer, Jan
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Bonn
Universität Bonn
Wolkenhauer, Olaf
Germany, Rostock
Universität Rostock
Evelo, Chris T.A.
Netherlands, Maastricht
Universiteit Maastricht
Hermjakob, Henning
United Kingdom, Hinxton
European Molecular Biology Laboratory
Sáez-Rodríguez, Julio
Germany, Heidelberg
Universität Heidelberg
Dopazo, Joaquin A.
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Spain, Sevilla
Csic-ja-use - Instituto de Biomedicina de Sevilla
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
Valencia, Alfonso
Spain, Barcelona
Centro Nacional de Supercomputación
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Kitano, Hiroaki
Japan, Okinawa
Okinawa Institute of Science and Technology Graduate University
Barillot, Emmanuel
France, Paris
Institut Curie
France, Paris
Inserm
France, Paris
Université Psl
Auffray, Charles
United Kingdom, Cambridge
Cancer Research uk Cambridge Institute
Balling, Rudi
Luxembourg, Esch-sur-alzette
University of Luxembourg
Schneider, Reinhard
Luxembourg, Esch-sur-alzette
University of Luxembourg
Statistics
Citations: 35
Authors: 40
Affiliations: 62
Identifiers
Doi:
10.15252/msb.202110387
ISSN:
17444292
Research Areas
Covid
Environmental
Health System And Policy
Study Design
Randomised Control Trial