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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Identification of a new subgroup of SIVagm in tantalus monkeys
Virology, Volume 197, No. 1, Article 71606, Year 1993
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Description
Simian immunodeficiency viruses from African green monkeys (SIVagm) can be classified into three subgroups based upon the species from which they were isolated. The most extensively studied subgroup are composed of SIVagm isolated from vervet monkeys (Cercopithicus pygerythrus). Fewer isolates have been characterized from either grivets (Cercopithicus aethiops) or green monkeys (Cercopithicus sabeus). An additional distinct species of African green monkeys, tantalus monkeys (Cercopithicus tantalus), has not been characterized in terms of SIV infection. A high seroprevalence of SIV-specific antibodies was identified in sera collected from Ugandan tantalus monkeys. SIV was isolated from PBMC (SIVagm/tan), the gag region amplified by polymerase chain reaction, cloned, and sequenced. Based upon gag, SIVagm/tan isolates cluster genetically with other previously recognized SIVagm strains. However, SIVagm from tantalus monkeys forms a distinct genetic subgroup. These data confirm earlier observations of species-specific subtypes of SIVagm viruses and support the hypothesis that these viruses may have coevolved with their host during geographic dispersion throughout Africa. © 1993 Academic Press, Inc.
Authors & Co-Authors
Hirsch, Vanessa M.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Washington, D.c.
Georgetown University
McGann, Christopher
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Dapolito, George
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Washington, D.c.
Georgetown University
Goldstein, Simoy Thomas
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Ogen-Odoi, Asaph A.
Uganda, Entebbe
Uganda Virus Research Institute
Biryawaho, Benon
Uganda, Entebbe
Uganda Virus Research Institute
Lakwo, Thomas
Uganda, Entebbe
Uganda Virus Research Institute
Johnson, Philip R.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
United States, Washington, D.c.
Georgetown University
United States, Columbus
The Ohio State University
Statistics
Citations: 8
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1006/viro.1993.1606
ISSN:
00426822
Research Areas
Genetics And Genomics