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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly
Cell Reports, Volume 42, No. 8, Article 112991, Year 2023
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Description
Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here, we show that individuals 70 years or older (median age 73, range 70–75) who received a primary two-dose schedule with AZD1222 and booster third dose with mRNA vaccine achieve significantly lower neutralizing antibody responses against SARS-CoV-2 spike pseudotyped virus compared with those younger than 70 (median age 66, range 54–69) at 1 month post booster. Impaired neutralization potency and breadth post third dose in the elderly is associated with circulating “atypical” spike-specific B cells expressing CD11c and FCRL5. However, when considering individuals who received three doses of mRNA vaccine, we did not observe differences in neutralization or enrichment in atypical B cells. This work highlights the finding that AdV and mRNA COVID-19 vaccine formats differentially instruct the memory B cell response. © 2023 The Authors
Authors & Co-Authors
Ferreira, Isabella A.T.M.
United Kingdom, Cambridge
Cambridge Institute of Therapeutic Immunology and Infectious Disease Citiid
United Kingdom, Cambridge
University of Cambridge
Abdullahi, Adam
United Kingdom, Cambridge
Cambridge Institute of Therapeutic Immunology and Infectious Disease Citiid
United Kingdom, Cambridge
University of Cambridge
Kemp, Steven A.
United Kingdom, Cambridge
Cambridge Institute of Therapeutic Immunology and Infectious Disease Citiid
United Kingdom, Cambridge
University of Cambridge
Ceron-Gutierrez, Lourdes
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Ebrahimi, Soraya
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Lyons, Paul A.
United Kingdom, Cambridge
Cambridge Institute of Therapeutic Immunology and Infectious Disease Citiid
United Kingdom, Cambridge
University of Cambridge
Collier, Dami Aderonke
United Kingdom, Cambridge
Cambridge Institute of Therapeutic Immunology and Infectious Disease Citiid
United Kingdom, Cambridge
University of Cambridge
McCoy, Laura E.
United Kingdom, London
University College London
Farooqi, Ismaa Sadaf
United Kingdom, Cambridge
Wellcome-mrc Institute of Metabolic Science
Teichmann, Sarah Amalia
United Kingdom, Hinxton
Wellcome Sanger Institute
MacAry, Paul Anthony
Singapore, Singapore City
National University of Singapore
Döffinger, Rainer
United Kingdom, Cambridge
Cambridge University Hospitals Nhs Foundation Trust
Wills, Mark R.
United Kingdom, Cambridge
Cambridge Institute of Therapeutic Immunology and Infectious Disease Citiid
United Kingdom, Cambridge
University of Cambridge
Linterman, Michelle A.
United Kingdom, Cambridge
The Babraham Institute
Clatworthy, Menna Ruth
United Kingdom, Cambridge
Cambridge Institute of Therapeutic Immunology and Infectious Disease Citiid
United Kingdom, Cambridge
University of Cambridge
United Kingdom, Cambridge
The Medical Research Council Laboratory of Molecular Biology
United Kingdom, Hinxton
Wellcome Sanger Institute
Gupta, Ravindra K.
United Kingdom, Cambridge
Cambridge Institute of Therapeutic Immunology and Infectious Disease Citiid
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 1
Authors: 16
Affiliations: 10
Identifiers
Doi:
10.1016/j.celrep.2023.112991
ISSN:
22111247
Research Areas
Covid