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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Imported Crimean-Congo hemorrhagic fever cases in Istanbul
BMC Infectious Diseases, Volume 7, Article 54, Year 2007
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Description
We described a series of imported cases of Crimean-Congo Hemorrhagic Fever (CCHF) in Istanbul and investigated the genetic diversity of the virus. All the suspected cases of CCHF, who were applied to the health centers in Istanbul, were screened for CCHF virus (CCHFv) infection by using semi-nested Polymerase Chain Reaction (PCR) following RT-PCR. Simultaneous blood samples were also sent to the national reference laboratory in Ankara for serologic investigation. In 10 out of 91 patients, CCHFv was detected by PCR, and among 9 out of 10, anti-CCHFv IgM antibodies were also positive. Clinical features were characterized by fever, myalgia, and hemorrhage. The levels of liver enzymes, creatinine phosphokinase, and lactate dehydrogenase were elevated, and bleeding markers were prolonged. All the cases were treated with ribavirin. There was no fatal case. All the strains clustered within the same group as other Europe/Turkey isolates. © 2007 Midilli et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Midilli, Kenan
Turkey, Istanbul
İstanbul University-cerrahpaşa Cerrahpaşa Faculty of Medicine
Gargili, Aysen
Turkey, Istanbul
İstanbul University-cerrahpaşa Cerrahpaşa Faculty of Medicine
Ergönül, Önder
Turkey, Istanbul
Marmara Üniversitesi
Şengöz, Gönül
Turkey, Ankara
T.c. Sağlık Bakanlığı,
Öztürk, Recep
Turkey, Istanbul
İstanbul University-cerrahpaşa Cerrahpaşa Faculty of Medicine
Bakar, Mehmet
Turkey, Ankara
T.c. Sağlık Bakanlığı,
Jongejan, Frans
Netherlands, Utrecht
Universiteit Utrecht
South Africa, Pretoria
University of Pretoria
Statistics
Citations: 7
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2334-7-54
e-ISSN:
14712334
Research Areas
Genetics And Genomics
Study Locations
Congo