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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy
Nature, Volume 303, No. 5915, Year 1983
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Description
In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens1-4. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2)5-8. Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells. © 1983 Nature Publishing Group.
Authors & Co-Authors
Haregewoin, Abebe
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Godal, Tore
Norway, Oslo
Rikshospitalet-radiumhospitalet hf
Mustafa, Abu Salim
Norway, Oslo
Rikshospitalet-radiumhospitalet hf
Belehu, Ayele
Ethiopia, Addis Ababa
Armauer Hansen Research Institute
Yemaneberhan, Tabebe
Ethiopia, Addis Ababa
All Africa Leprosy, Tuberculosis and Rehabilitation Training Centre Addis Ababa
Statistics
Citations: 115
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1038/303342a0
ISSN:
00280836