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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Use of lipid-based nutrient supplements by HIV-infected malawian women during lactation has no effect on infant growth from 0 to 24 weeks
Journal of Nutrition, Volume 142, No. 7, Year 2012
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Description
The Breastfeeding, Antiretrovirals, and Nutrition Study evaluated the effect of daily consumption of lipid-based nutrient supplements (LNS) by 2121 lactating, HIV-infected mothers on the growth of their exclusively breast-fed, HIV-uninfected infants from 0 to 24 wk. The study had a 2 × 3 factorial design. Malawian mothers with CD4+≥250 cells/mm3, hemoglobin ≥70 g/L, and BMI ≥17 kg/m2 were randomized within 36 h of delivery to receive either no LNS or 140 g/d of LNS to meet lactation energy and protein needs, and mother-infant pairs were assigned to maternal antiretroviral drugs (ARV), infant ARV, or no ARV. Sex-stratified, longitudinal, random effects models were used to estimate the effect of the 6 study arms on infant weight, length, and BMI. Logistic regression models were used to calculate the odds of growth faltering [decline in weight-for-age Z-score (WAZ) or length-for-age Z-score (LAZ) >0.67] using the control arm as the reference. Although some differences between study arms emerged with increasing infant age in boys, there were no consistent effects of the maternal supplement across the 3 growth outcomes in longitudinal models. At the ages where differences were observed, the effects on weight and BMI were quite small (≤200 g and ≤0.4 kg/m2) and unlikely to be of clinical importance. Overall, 21 and 34% of infants faltered in WAZ and LAZ, respectively. Maternal supplementation did not reduce the odds of infant weight or length faltering from 0 to 24 wk in any arm. These results indicate that blanket supplementation of HIV-infected lactating women may have little impact on infant growth. © 2012 American Society for Nutrition.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3374670/bin/supp_142_7_1350__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3374670/bin/supp_jn.111.155598_nut155598-SFig_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3374670/bin/supp_jn.111.155598_nut155598-ST1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3374670/bin/supp_jn.111.155598_nut155598-ST2.pdf
Authors & Co-Authors
Flax, Valerie L.
United States, Chapel Hill
Carolina Population Center
Bentley, Margaret E.
United States, Chapel Hill
Carolina Population Center
United States, Chapel Hill
Unc School of Medicine
Chasela, Charles S.
Malawi, Lilongwe
Unc Project-malawi
South Africa, Johannesburg
University of the Witwatersrand
Kayira, Dumbani
Malawi, Lilongwe
Unc Project-malawi
Hudgens, Michael G.
United States, Chapel Hill
Unc School of Medicine
Knight, Rodney J.
United States, Chapel Hill
Principia
Soko, Alice
Malawi, Lilongwe
Unc Project-malawi
Jamieson, Denise J.
United States, Atlanta
Centers for Disease Control and Prevention
van der Horst, Charles Michael
United States, Chapel Hill
Unc School of Medicine
Adair, Linda S.
United States, Chapel Hill
Carolina Population Center
United States, Chapel Hill
Unc School of Medicine
Statistics
Citations: 21
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.3945/jn.111.155598
ISSN:
00223166
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Participants Gender
Male
Female