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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
Nature Medicine, Volume 1, No. 2, Year 1995
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Description
Although 13 years have passed since identification of human immunodeficiency virus-1 (HIV-1) as the cause of AIDS, we do not yet know how HIV kills its primary target, the T cell that carries the CD4 antigen. We and others have shown an increase in the percentage of apoptotic cells among circulating CD4+ (and CD8+) T cells of HIV-seropositive individuals and an increase in frequency of apoptosis with disease progression. However, it is not known if this apoptosis occurs in infected or uninfected T cells. We show here, using in situ labelling of lymph nodes from HIV-infected children and SIV-infected macaques, that apoptosis occurs predominantly in bystander cells and not in the productively infected cells themselves. These data have implications for pathogenesis and therapy, namely, arguing that rational drug therapy may involve combination agents targeting viral replication in infected cells and apoptosis of uninfected cells. © 1995 Nature Publishing Group.
Authors & Co-Authors
Finkel, T. Helman
United States, Denver
National Jewish Medical and Research Center
United States, Aurora
University of Colorado Anschutz Medical Campus
Tudor-Williams, Gareth
United States, Rockville
National Cancer Institute Nci
Cotton, Mark Fredric
United States, Aurora
University of Colorado Anschutz Medical Campus
Ruprecht, Ruth M.
United States, Boston
Dana-farber Cancer Institute
Statistics
Citations: 823
Authors: 4
Affiliations: 5
Identifiers
Doi:
10.1038/nm0295-129
ISSN:
10788956
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health