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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers
Journal of Exposure Science and Environmental Epidemiology, Volume 22, No. 3, Year 2012
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Description
Biomonitoring of effects in agricultural workers is necessary to assess the individual risk of handling pesticides. In this study, biochemical and haematological parameters were measured to evaluate the effects of exposure to these compounds in agricultural workers. The study was carried out in 110 workers and 97 control subjects. Several haematological and biochemical parameters were analysed. Assessment of haematological parameters revealed that the mean cell volume and haematocrit levels were significantly lower in workers than in controls (P=.002 and 0.013, respectively), while mean corpuscular haemoglobin concentrations were higher in workers (P<.001). There was also a significant inhibition of butyrylcholinesterase activity in workers compared with that in controls (P<.001). Assessment of biochemical parameters further showed significantly higher activities of transferases, lactate dehydrogenase (P<.001), alkaline phosphatase (ALP) (P<.006) and creatine kinase (CK) (P<.015), as well as higher levels of proteins (P<.001), creatinine (P<.001) and urea (P0.001) in workers compared with controls, along with significantly higher uric acid levels (P<.012). Furthermore, the number of years exposed to pesticides predicted higher activities of alanine aminotransferase, CK, ALP, as well as uric acid levels. Overall, chronic exposure to pesticides appeared to affect several biochemical parameters. These biomarkers seem to be indicative of adverse effects of pesticides in agricultural workers, confirming their use for routine monitoring of effects .© 2012 Macmillan Publishers Limited All rights reserved.
Authors & Co-Authors
Araoud, Manel
Tunisia, Monastir
Faculté de Médecine de Monastir
Tunisia, Monastir
Chu Fattouma-bourguiba
Neffati, Fadoua
Tunisia, Monastir
Chu Fattouma-bourguiba
Douki, Wahiba
Tunisia, Monastir
Chu Fattouma-bourguiba
Hfaiedh, Hassen Ben
Tunisia, Monastir
Faculté de Médecine de Monastir
Akrout, Mohamed
Tunisia, Monastir
Faculté de Médecine de Monastir
Hassine, Mohssen
Tunisia, Monastir
Chu Fattouma-bourguiba
Najjar, M. F.
Tunisia, Monastir
Chu Fattouma-bourguiba
Kénani, Abderraouf
Tunisia, Monastir
Faculté de Médecine de Monastir
Statistics
Citations: 41
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1038/jes.2012.11
ISSN:
15590631
e-ISSN:
1559064X