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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Passive cigarette smoking increases isoprostane formation
Life Sciences, Volume 78, No. 8, Year 2006
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Description
Passive smoking has been demonstrated to exert a variety of deleterious effects eventually resulting in vascular damage. Isoprostanes, a reliable marker of in vivo oxidation injury, have been shown to increase in active cigarette smoking. Data for passive smoking are lacking. We were examining the isoprostane 8-epi-PGF2α in 12 smokers and non-smokers exposed daily to passive cigarette smoke for 12 days. Plasma samples stored at liquid nitrogen from people having been examined earlier were used. Prevalues of 8-epi-PGF 2α are higher in cigarette smokers. Exposure to passive smoking causes a significant increase in 8-epi-PGF2α in non-smokers, while in smokers there is only a trendwise increase. After repeated passive smoke exposure, 8-epi-PGF2α in non-smokers approaches the respective values of smokers. There is a significant correlation of 8-epi-PGF2α to the thromboxane (plasma, serum, conversion from exogenous precursor, 11-dehydro-TXB2) parameters (MDA, HHT- conversion) examined in these patients before. The findings document a significant temporary increase in in vivo oxidation injury due to passive smoke favouring development and/or progression of vascular disease. © 2005 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Ahmadzadehfar, Hossein
Austria, Vienna
Wilhelm Auerswald Atherosclerosis Research Group
Iran, Rasht
University of Guilan
Oguogho, Anthony
Austria, Vienna
Wilhelm Auerswald Atherosclerosis Research Group
Nigeria, Ekpoma
Ambrose Alli University
Efthimiou, Yannis
Austria, Vienna
Austrian-greek Atherosclerosis Prevention Initiative
Greece, Athens
Austrian-greek Atherosclerosis Prevention Initiative
Kritz, Harald
Austria, Vienna
Wilhelm Auerswald Atherosclerosis Research Group
Sinzinger, Helmut F.
Austria, Vienna
Wilhelm Auerswald Atherosclerosis Research Group
Austria, Vienna
Institute for Diagnosis and Treatment of Lipid Disorders and Atherosclerosis Athos
Austria, Vienna
Austrian-greek Atherosclerosis Prevention Initiative
Greece, Athens
Austrian-greek Atherosclerosis Prevention Initiative
Statistics
Citations: 38
Authors: 5
Affiliations: 6
Identifiers
Doi:
10.1016/j.lfs.2005.05.099
ISSN:
00243205
Research Areas
Substance Abuse
Violence And Injury