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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10
Nature, Volume 328, No. 6130, Year 1987
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Description
Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3). © 1987 Nature Publishing Group.
Authors & Co-Authors
Mathew, Christopher G.
United Kingdom, London
The Institute of Cancer Research
Chin, K. S.
United Kingdom, London
The Institute of Cancer Research
d'Adamo, Adamo P.
United Kingdom, London
The Institute of Cancer Research
Thorpe, K.
United Kingdom, London
The Institute of Cancer Research
Carter, C.
United Kingdom, London
The Institute of Cancer Research
Liou, Gregory Ing
United States, Houston
Baylor College of Medicine
Fong, S. L.
United States, Houston
Baylor College of Medicine
Bridges, C. D.B.
United States, Houston
Baylor College of Medicine
Haak, Harm R.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Kruseman, A. C.Nieuwenhuijzen
Netherlands, Leiden
Leids Universitair Medisch Centrum
Schifter, S.
Denmark, Aarhus
Aarhus Universitetshospital
Hansen, H. H.
Denmark, Aarhus
Aarhus Universitetshospital
Telenius, Håkan
Sweden
Hässleholm Hospital
Telenius-berg, Margareta
Kuwait, Kuwait City
Kuwait University
Ponder, Bruce A.J.
United Kingdom, London
The Institute of Cancer Research
Statistics
Citations: 433
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1038/328527a0
ISSN:
00280836
Research Areas
Cancer
Genetics And Genomics