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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Burden of invasive disease caused by Haemophilus influenzae type b in Bamako, Mali: Impetus for routine infant immunization with conjugate vaccine
Pediatric Infectious Disease Journal, Volume 24, No. 6, Year 2005
Notification
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Description
Background: Population-based, bacteriologically confirmed disease burden data aid decision makers in African countries pondering whether to introduce Haemophilus influenzae type b (Hib) immunization for infants. Methods: A bacteriology laboratory was established in Hôpital Gabriel Touré, serving Bamako, Mali. Children age 0-15 years with fever ≥39°C or syndromes compatible with invasive bacterial disease (meningitis, etc.) were eligible. From 2 to 5 mL of blood or relevant body fluid were inoculated into Bactec Ped Plus/F medium for automated culture; body fluids were also inoculated directly onto solid media. Hib was confirmed by standard microbiologic techniques and antibiograms generated by disk diffusion. Results: From June 1, 2002 to May 31, 2004, 3592 (87.8%) of 4092 children admitted to Hôpital Gabriel Touré with high fever or suspected invasive bacterial disease were cultured, including 1745 who were 0-11 months old, 1132 who were 1-4 years old and 715 who were 5-15 years old. Hib was isolated from 207 Bamako children, 81 from blood alone and 124 from cerebrospinal fluid (with or without positive blood culture). Of 207 cases 204 (98.5%) occurred in children younger than age 5 years (annual incidence, 45.2/105) and 159 (77%) in infants age 0-11 months (annual incidence, 158.4/105). Peak incidence (370.0 cases/105) and 12 of 21 Hib deaths occurred in 6- to 7-month-olds. Of the Hib isolates, 11.1% were resistant to ampicillin, 32% to chloramphenicol and 0.5% to ceftriaxone. Conclusions: The substantial burden of invasive Hib disease documented in Bamako has prompted the Malian government to introduce routine infant immunization with Hib conjugate. Copyright © 2005 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Sow, Samba Ousmane
Mali, Bamako
Centre Pour le Développement Des Vaccins
Diallo, Souleymane M’bara
Mali, Bamako
Gabriel Toure Hospital
Campbell, James D.
United States, Baltimore
University of Maryland School of Medicine
Tapia, Milagritos D.
United States, Baltimore
University of Maryland School of Medicine
Kéita, Tatiana F.
Mali, Bamako
Gabriel Toure Hospital
Kéita, Mamadou Marouf
Mali, Bamako
Gabriel Toure Hospital
Murray, Patrick R.
United States, Bethesda
National Institutes of Health Nih
Kotloff, Karen L.
United States, Baltimore
University of Maryland School of Medicine
Levine, Myron M.
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 34
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1097/01.inf.0000164768.28135.0d
ISSN:
08913668
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Mali