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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Mosaic structure of foot-and-mouth disease virus genomes
Journal of General Virology, Volume 88, No. 2, Year 2007
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Description
The results of a simple pairwise-scanning analysis designed to identify inter-serotype recombination fragments, applied to genome data from 156 isolates of Foot-and-mouth disease virus (FMDV) representing all seven serotypes, are reported. Large numbers of candidate recombinant fragments were identified from all parts of the FMDV genome, with the exception of the capsid genes, within which such fragments are infrequent. As expected, intertypic fragment exchange is most common between geographically sympatric FMDV serotypes. After accounting for the likelihood of intertypic convergence in highly conserved parts of the FMDV genome, it is concluded that intertypic recombination is probably widespread throughout the non-structural genes, but that recombination over the 2B/C and 3B/C gene boundaries appears to be less frequent than expected, given the large numbers of recombinant gene fragments arising in these genes. © 2007 SGM.
Authors & Co-Authors
Jackson, Andrew L.
United Kingdom, Glasgow
University of Glasgow
Ireland, Dublin
Trinity College Dublin
O'Neill, Hester Gertruida
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
South Africa, Cape Town
University of Cape Town
Maree, Francois Frederick
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
Blignaut, Belinda
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
Carrillo, C.
United States, Greenport
Usda Ars Plum Island Animal Disease Center
Rodríguez, Luis L. L.
United States, Greenport
Usda Ars Plum Island Animal Disease Center
Haydon, Daniel Thomas
United Kingdom, Glasgow
University of Glasgow
Statistics
Citations: 66
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1099/vir.0.82555-0
ISSN:
00221317
Research Areas
Genetics And Genomics