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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Immunoepidemiologic profile of Chlamydia trachomatis infection: Importance of heat-shock protein 60 and interferon-γ
Journal of Infectious Diseases, Volume 192, No. 4, Year 2005
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Description
Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study of women at high risk for C. trachomatis infection, we found that, at baseline and after adjustment for age and other potential confounding variables, production of interferon-γ by peripheral-blood mononuclear cells (PBMCs) stimulated with chlamydia heat-shock protein 60 strongly correlated with protection against incident C. trachomatis infection. This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Cohen, Craig R.
United States, San Francisco
University of California, San Francisco
Koochesfahani, Kasra M.
Canada, Vancouver
The University of British Columbia
Magaret, Amalia Meier
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Shen, Caixia
Canada, Vancouver
The University of British Columbia
Karunakaran, Karuna P.
Canada, Vancouver
The University of British Columbia
Ondondo, Beatrice Omusiro
Kenya, Nairobi
University of Nairobi
Kinyari, Teresa
Kenya, Nairobi
University of Nairobi
Mugo, Nelly Rwamba
Kenya, Nairobi
University of Nairobi
Nguti, Rosemary
Kenya, Nairobi
University of Nairobi
Brunham, Robert C.
Canada, Vancouver
The University of British Columbia
Canada, Vancouver
University of British Columbia, Faculty of Medicine
Statistics
Citations: 125
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1086/432070
ISSN:
00221899
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female