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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Cytotoxicity mechanisms in melanoma cells and UPLC-QTOF/MS2 chemical characterization of two Brazilian stingless bee propolis: Uncommon presence of piperidinic alkaloids
Journal of Pharmaceutical and Biomedical Analysis, Volume 149, Year 2018
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Description
The present study characterized propolis extracts produced by Scaptotrigona bipunctata (Tubuna) and Melipona quadrifasciata (Mandaçaia) by LC–MS/MS; their cytotoxicity as well as the mechanism of action in a melanoma cellular model were also assessed. The chemical characterization performed by UPLC-ESI-QTOF/MS2 analysis revealed uncommon presence of piperidinic alkaloids in Tubuna's propolis extract together with C-glycopyranoside flavonoids. Mandaçaia's propolis collected in the same area rather presented terpenoids and flavonoids. Regarding the mechanism of cytotoxicity, propolis extracts increased the accumulation of reactive oxygen species (ROS), reduced the potential of mitochondrial membrane, induced a decrease in the proteins Bcl-2 and AKT-3 levels, and decreased melanoma cells’ migration and invasion. Both propolis extracts induced apoptosis while only Mandaçaia's propolis extract induced cell cycle arrest in G2/M. © 2017 Elsevier B.V.
Authors & Co-Authors
Cisilotto, Júlia
Brazil, Florianopolis
Universidade Federal de Santa Catarina
Sandjo, Louis P.
Brazil, Florianopolis
Universidade Federal de Santa Catarina
Biavatti, Maique Weber
Brazil, Florianopolis
Universidade Federal de Santa Catarina
Creczynski-Pasa, Tânia Beatriz
Brazil, Florianopolis
Universidade Federal de Santa Catarina
Statistics
Citations: 34
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.jpba.2017.11.038
ISSN:
07317085
Research Areas
Cancer