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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Host-specific genetic variation of highly pathogenic avian influenza viruses (H5N1)
Virus Genes, Volume 42, No. 3, Year 2011
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Description
The complete genome sequences of two isolates A/chicken/Egypt/CL6/07 (CL6/07) and A/duck/Egypt/D2br10/07 (D2br10/07) of highly pathogenic avian influenza virus (HPAI) H5N1 isolated at the beginning of 2007 outbreak in Egypt were determined and compared with all Egyptian HPAI H5N1 sequences available in the GenBank. Sequence analysis utilizing the RNA from the original tissue homogenate showed amino acid substitutions in seven of the viral segments in both samples. Interestingly, these changes were different between the CL6/07 and D2br10/07 when compared to other Egyptian isolates. Moreover, phylogenetic analysis showed independent sub-clustering of the two viruses within the Egyptian sequences signifying a possible differential adaptation in the two hosts. Further, pre-amplification analysis of H5N1 might be necessary for accurate data interpretation and identification of distinct factor(s) influencing the evolution of the virus in different poultry species. © 2011 The Author(s).
Authors & Co-Authors
Ibrahim, Madiha Salah
Japan, Suita
Research Institute for Microbial Diseases
Egypt, Damanhour
Faculty of Veterinary Medicine
Watanabe, Yohei
Japan, Suita
Research Institute for Microbial Diseases
Ellakany, Hany F.
Egypt, Alexandria
Faculty of Veterinary Medicine
Yamagishi, Aki
Japan, Suita
Research Institute for Microbial Diseases
Sapsutthipas, Sompong
Japan, Suita
Research Institute for Microbial Diseases
Toyoda, Tetsuya
China, Shanghai
Institut Pasteur of Shanghai, Chinese Academy of Sciences
Abd El-Hamied, H. S.
Egypt, Damanhour
Faculty of Veterinary Medicine
Ikuta, Kazuyoshi
Japan, Suita
Research Institute for Microbial Diseases
Statistics
Citations: 8
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1007/s11262-011-0583-y
ISSN:
09208569
e-ISSN:
1572994X
Research Areas
Genetics And Genomics
Study Locations
Egypt