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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa
G3: Genes, Genomes, Genetics, Volume 3, No. 6, Year 2013
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Description
Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world. It is an Epstein-Barr virus2associated malignancy with an unusual racial and geographical distribution. The host innate immune sensor genes play an important role in infection recognition and immune response against viruses. Therefore, we examined the association between polymorphisms in genes within a group of pattern recognition receptors (including families of Toll-like receptors, C-type lectin receptors, and retinoic acid2inducible gene I2like receptors) and NPC susceptibility. Twenty-six single-nucleotide polymorphisms (SNPs) in five pattern-recognition genes were genotyped in 492 North African NPC cases and 373 frequency-matched controls. TLR3_rs3775291 was the most significantly associated SNP (odds ratio [OR] 1.49; 95% confidence interval [95% CI] 1.1122.00; P = 0.008; dominant model). The analysis showed also that CD209_rs7248637 (OR 0.69; 95% CI 0.5220.93; P = 0.02; dominant model) and DDX58_rs56309110 (OR 0.70; 95% CI 0.5120.98; P = 0.04) were associated with the risk of NPC. An 18% increased risk per allele was observed for the five most significantly associated SNPs, TLR3_rs3775291, CD209_rs7248637, DDX58_rs56309110, CD209_rs4804800, and MBL2_rs10824792, (ptrend = 8.2×10-4). Our results suggest that genetic variation in pattern-recognition genes is associated with the risk of NPC. These preliminary findings require replication in larger studies. © 2013 Moumad et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3689808/bin/supp_3_6_971__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3689808/bin/supp_g3.112.005371_FigureS1.pdf
Authors & Co-Authors
Moumad, Khalid
Germany, Heidelberg
German Cancer Research Center
Morocco, Casablanca
Institut Pasteur du Maroc
Morocco, Mohammedia
Faculté Des Sciences et Techniques de Mohammedia
Lascorz, Jesus
Germany, Heidelberg
German Cancer Research Center
Bevier, Melanie
Germany, Heidelberg
German Cancer Research Center
Khyatti, Meriem
Morocco, Casablanca
Institut Pasteur du Maroc
Ennaji, M. M.
Morocco, Mohammedia
Faculté Des Sciences et Techniques de Mohammedia
Benider, Abdellatif
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Huhn, Stefanie
Germany, Heidelberg
German Cancer Research Center
Lu, Shun
Germany, Heidelberg
German Cancer Research Center
Chouchane, Lotfi
Qatar, Doha
Weill Cornell Medicine-qatar
Corbex, Marilys Anne
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Hemminki, Kari
Germany, Heidelberg
German Cancer Research Center
Sweden, Lund
Lunds Universitet
Försti, Asta
Germany, Heidelberg
German Cancer Research Center
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Statistics
Citations: 24
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1534/g3.112.005371
e-ISSN:
21601836
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study
Study Locations
Multi-countries