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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Mass spectrometrical analysis of galectin proteins in primary rat cerebellar astrocytes
Neurochemical Research, Volume 31, No. 7, Year 2006
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Description
Galectins are a family of animal lectins with specificity for β-galactosides and are involved in a host of cellular activities, ranging from development to cancer. The molecules are expressed by neural and non-neural cells intracellularly as well as extracellularly. Using two-dimensional gel electrophoresis coupled to tandem mass spectrometry, the present work aimed to identify and characterize galectins in primary rat cerebellar astrocytes. The protein-chemical method identified nine spots representing two members of the galectin family, namely galectin-1 and galectin-3. These findings suggest that high abundant expression of galectin in astrocytes is limited to the two abundant galectin family members. As these family members are linked to human astrocytic tumors, their reliable detection in astrocytes by proteomic techniques would enable us to further understand their role in neural development, injury, and regeneration in general and astrocytoma in particular. © Springer Science+Business Media, Inc. 2006.
Authors & Co-Authors
Yang, Jae-won
Austria, Vienna
Medizinische Universität Wien
Kang, Sungung
Austria, Vienna
Medizinische Universität Wien
Engidawork, Ephrem
Austria, Vienna
Medizinische Universität Wien
Ethiopia, Addis Ababa
Addis Ababa University
Rodrigo, Regina
Spain, Valencia
Laboratorio de Neurobiologia de Prince Felipe Research Centre
Felipo, Vicente
Spain, Valencia
Laboratorio de Neurobiologia de Prince Felipe Research Centre
Lübec, Gert
Austria, Vienna
Medizinische Universität Wien
Statistics
Citations: 10
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1007/s11064-006-9100-4
Research Areas
Cancer
Violence And Injury