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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Onchocerca volvulus dna probe classification correlates with epidemiologic patterns of blindness
Journal of Infectious Diseases, Volume 165, No. 5, Year 1992
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Description
Onchocerciasis, or river blindness, results from infection with Onchocerca volvulus. The parasite is endemic to West Africa, in both rain forest and savanna bioclimes. Several lines of evidence suggest that different strains of the parasite exist in the rain forest and savanna. Furthermore, epidemiologic evidence indicates that ocular onchocerciasis is most severe in savanna regions. This has led to the hypothesis that there is a strain association with ocular pathology. To test this hypothesis, parasites from villages in which severe and mild onchocerciasis were endemic were classified with two strain-specific DNA probes. A strong correlation (P <.001) was found between disease severity and probe recognition, supporting the hypothesis that pathogenic-ity is strain related. The results suggest that pFS-1 and pSS-1BT may be used to predict the pathogenic potential of parasite populations throughout much of West Africa. © 1992 The University of Chicago.
Authors & Co-Authors
Zimmerman, Peter A.
United States, Birmingham
The University of Alabama at Birmingham
United States, Cleveland
Case Western Reserve University
Burkina Faso, Ouagadougou
Ouagadougou
Switzerland, Geneva
Organisation Mondiale de la Santé
Dadzie, Kofi Yankum
United States, Birmingham
The University of Alabama at Birmingham
United States, Cleveland
Case Western Reserve University
Burkina Faso, Ouagadougou
Ouagadougou
De Sole, G.
United States, Birmingham
The University of Alabama at Birmingham
United States, Cleveland
Case Western Reserve University
Burkina Faso, Ouagadougou
Ouagadougou
Remme, Jan Hans F.
United States, Birmingham
The University of Alabama at Birmingham
United States, Cleveland
Case Western Reserve University
Burkina Faso, Ouagadougou
Ouagadougou
Soumbey-Alley, Edoh William
United States, Birmingham
The University of Alabama at Birmingham
United States, Cleveland
Case Western Reserve University
Burkina Faso, Ouagadougou
Ouagadougou
Unnasch, Thomas Raymond
United States, Birmingham
The University of Alabama at Birmingham
United States, Cleveland
Case Western Reserve University
Burkina Faso, Ouagadougou
Ouagadougou
Statistics
Citations: 120
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/165.5.964
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries