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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cellular and humoral responses to influenza in Gabonese children living in rural and semi-urban areas
Journal of Infectious Diseases, Volume 196, No. 11, Year 2007
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Description
Background. With the current attention to the pandemic threat of avian influenza viruses, it is recognized that there is little information on influenza in Africa. In addition, the effects of influenza vaccination in African countries could be very different from the effects in regions with less exposure to microorganisms and parasites. Methods. To monitor the presence of influenza viruses and investigate the immunological responses to influenza vaccination, schoolchildren in semi-urban and rural regions of Gabon were studied. Influenza-specific antibody responses to the 3 strains represented in the vaccine were determined in the serum. Furthermore, cytokine responses were measured after in vitro stimulation of whole blood by influenza antigens, before and after vaccination. Results. Prevaccination titers of antibody against H3N2 were high. At vaccination, the titers of antibody against the 3 influenza strains increased significantly. The anti-H1N1 and anti-B responses after vaccination were weaker in rural schoolchildren than in semi-urban schoolchildren. Influenza-specific cytokine responses were induced within a week, showing significantly lower interferon-γ and significantly higher interleukin-5 in the children from rural areas. Conclusions. Prevaccination antibody levels indicated that influenza viruses circulate in Gabon. Altogether, influenza vaccination induces weaker immune responses in a rural population than in a semi-urban population of Gabonese schoolchildren. © 2007 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
van Riet, E.
Unknown Affiliation
Adégnika, Ayôla Akim
Unknown Affiliation
Retra, Kim
Unknown Affiliation
Vieira, R.
Unknown Affiliation
Tielens, Aloysius G.M.
Unknown Affiliation
Lell, Bertrand
Unknown Affiliation
Issifou, Saadou
Unknown Affiliation
Hartgers, Franca C.
Unknown Affiliation
Rimmelzwaan, Guus F.
Unknown Affiliation
Kremsner, Peter G.
Unknown Affiliation
Yazdanbakhsh, Maria M.
Unknown Affiliation
Statistics
Citations: 66
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1086/522010
ISSN:
00221899
Research Areas
Maternal And Child Health
Study Design
Cross Sectional Study
Study Locations
Gabon