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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Oropharyngeal colonization by Streptococcus pneumoniae among HIV-infected adults in Uganda: assessing prevalence and antimicrobial susceptibility
International Journal of Infectious Diseases, Volume 10, No. 6, Year 2006
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Description
Objectives: To evaluate characteristics of Streptococcus pneumoniae associated with oropharyngeal colonization in the Ugandan adult HIV population. Methods: We conducted a cross-sectional study at the outpatient HIV clinic at the Joint Clinical Research Centre in Kampala, Uganda between July 2004 and February 2005. Six hundred HIV-infected individuals were interviewed and had oropharyngeal specimens collected. Pneumococci were isolated from these specimens and antimicrobial susceptibility patterns determined using standard microdilution methods. Serotypes of the pneumococcal isolates were evaluated by capsular swelling reaction with commercial antisera. Results: The prevalence of oropharyngeal colonization with pneumococci was 18% (108/600). Thirty-two different pneumococcal serotypes were identified, and the most common were serotypes 3 (14.7%), 19F (6.4%), 23F (6.4%), and 16 (5.5%). Seventy-two percent of the isolates were penicillin (PCN) intermediate (MICs 0.12-1 μg/mL), the remainder all being PCN susceptible, and >99% were trimethoprim-sulfamethoxazole (TMP-SMX) resistant. Novel PCN intermediate serotypes included 7, 11, 16, 20, 22, 24, and 34. Only one isolate was resistant to macrolides, and resistance to other antibiotics was rare. Conclusions: HIV-infected adults in Uganda are colonized with pneumococci that exhibit a high degree of TMP-SMX and PCN non-susceptibility, with several unique PCN non-susceptible serotypes that are not included in current vaccine preparations. © 2006 International Society for Infectious Diseases.
Authors & Co-Authors
Blossom, David B.
United States, Cleveland
Case Western Reserve University
United States, Cleveland
University Hospitals Case Medical Center
Namayanja-Kaye, Grace
Uganda, Kampala
Joint Clinical Research Center Uganda
Nankya-Mutyoba, Joan
Uganda, Kampala
Joint Clinical Research Center Uganda
Mukasa, J. B.
Uganda, Kampala
Joint Clinical Research Center Uganda
Bakka, Henry
Uganda, Kampala
Joint Clinical Research Center Uganda
Rwambuya, Sandra
Uganda, Kampala
Joint Clinical Research Center Uganda
Windau, Anne R.
United States, Cleveland
Case Western Reserve University
Bajaksouzian, Saralee
United States, Cleveland
Case Western Reserve University
Walker, Courtney J.
United States, Cleveland
Case Western Reserve University
Joloba, Moses Lutaakome
Uganda, Kampala
Makerere University
Kityo, Cissy Mutuluuza
Uganda, Kampala
Joint Clinical Research Center Uganda
Mugyenyi, Peter N.
Uganda, Kampala
Joint Clinical Research Center Uganda
Whalen, Christopher Curtis
United States, Cleveland
Case Western Reserve University
Jacobs, Michael R.
United States, Cleveland
Case Western Reserve University
United States, Cleveland
University Hospitals Case Medical Center
Salata, Robert A.
United States, Cleveland
Case Western Reserve University
United States, Cleveland
University Hospitals Case Medical Center
Statistics
Citations: 35
Authors: 15
Affiliations: 4
Identifiers
Doi:
10.1016/j.ijid.2006.05.010
ISSN:
12019712
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Uganda