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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Reduction of the efficacy of antifolate antimalarial therapy by folic acid supplementation
American Journal of Tropical Medicine and Hygiene, Volume 73, No. 1, Year 2005
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Description
Malaria and anemia are common conditions in patients presenting to outpatient clinics in Kenya. Anemia is usually due to malaria infection with underlying micronutrient deficiency. Iron therapy has been shown to enhance recovery from anemia in children with malaria, without affecting malaria treatment. Iron and folic acid are often prescribed together for anemic individuals. Until recently in Kenya, the drug of first choice for non-severe malaria was sulfadoxine-pyrimethamine (SP), an antifolate antimalarial drug. In this study, 303 patients of all ages with anemia and uncomplicated Plasmodium falciparum malaria attending an outpatient clinic in an area of seasonal malaria were treated with SP and iron, and were randomized to receive folic acid. Parasite clearance rates were measured using a survival analysis plot for both parasitologic and clinical failure. There was a significant reduction in the efficacy of SP in patients taking standard therapeutic doses of folic acid using the survival curve for parasitologic failure (P < 0.0001), but no difference for clinical failure (P = 0.7008). Folic acid supplementation did not enhance recovery from anemia. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Carter, Jane Y.
Kenya, Nairobi
Amref Health Africa
Loolpapit, Mores
Kenya, Nairobi
Amref Health Africa
Lema, Orgenes E.
Kenya, Nairobi
Amref Health Africa
Tome, Julius L.
Kenya, Nairobi
Amref Health Africa
Nagelkerke, Nico J.D.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Watkins, Williams M.
United Kingdom, Liverpool
University of Liverpool
Statistics
Citations: 69
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2005.73.166
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Kenya