Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Time is of the essence: Exploring a measles outbreak response vaccination in Niamey, Niger
Journal of the Royal Society Interface, Volume 5, No. 18, Year 2008
Notification
URL copied to clipboard!
Description
The current World Health Organization recommendations for response during measles epidemics focus on case management rather than outbreak response vaccination (ORV) campaigns, which may occur too late to impact morbidity and mortality and have a high cost per case prevented. Here, we explore the potential impact of an ORV campaign conducted during the 2003-2004 measles epidemic in Niamey, Niger. We measured the impact of this intervention and also the potential impact of alternative strategies. Using a unique geographical, epidemiologic and demographic dataset collected during the epidemic, we developed an individual-based simulation model. We estimate that a median of 7.6% [4.9-8.9] of cases were potentially averted as a result of the outbreak response, which vaccinated approximately 57% (84563 of an estimated 148600) of children in the target age range (6-59 months), 23 weeks after the epidemic started. We found that intervening early (up to 60 days after the start of the epidemic) and expanding the age range to all children aged 6 months to 15 years may lead to a much larger (up to 90%) reduction in the number of cases in a West African urban setting like Niamey. Our results suggest that intervening earlier even with lower target coverage (approx. 60%), but a wider age range, may be more effective than intervening later with high coverage (more than 90%) in similar settings. This has important implications for the implementation of reactive vaccination interventions as they can be highly effective if the response is fast with respect to the spread of the epidemic. © 2007 The Royal Society.
Authors & Co-Authors
Grais, Rebecca Freeman
France, Paris
Epicentre
Conlan, Andrew J.K.
United Kingdom, Cambridge
University of Cambridge
Ferrari, Matthew J.
United States, University Park
Pennsylvania State University
Djibo, Ali
Niger
Ministry of Health
Le Menach, Arnaud
France, Paris
Inserm
Bjornstad, Ottar Nordal
United States, University Park
Pennsylvania State University
United States, Bethesda
National Institutes of Health Nih
Grenfell, Bryan T.
United States, University Park
Pennsylvania State University
United States, Bethesda
National Institutes of Health Nih
Statistics
Citations: 84
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1098/rsif.2007.1038
ISSN:
17425689
e-ISSN:
17425662
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Phenomenological Study
Study Locations
Niger