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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
nursing
Age Differences by Sex in Antiretroviral-Naïve Participants: Pooled Analysis from Randomized Clinical Trials
Journal of the Association of Nurses in AIDS Care, Volume 29, No. 3, Year 2018
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Description
Age and sex effects on antiretroviral therapy (ART) response are not well elucidated. Our pooled analysis of 40 randomized clinical trials measured the association of age and sex on CD4+ T cell count changes and virologic suppression using multivariable regression modeling. The average increase in CD4+ T cell count from baseline to week 48 was 17.3 cells/mm 3 lower and clinically insignificant (95% confidence interval −30.8 to −3.8) among women ages ≥ 50 years (n = 573), compared to women ≤ 35 years (n = 3,939). Results were similar for men. Virologic suppression odds were 60% and 21% times greater among participants ≥50 years compared to ≤35 years, in women and men, respectively. In both sexes, larger increases in CD4+ T cell count changes were observed in younger, compared to older, participants; however, virologic suppression was higher in older, compared to younger, participants suggesting a non-sex-specific age effect response to ART. © 2018
Authors & Co-Authors
Tracy, La Ree A.
Unknown Affiliation
Struble, Kimberly A.
Unknown Affiliation
Firnhaber, Cynthia S.
Unknown Affiliation
Smeaton, Laura M.
Unknown Affiliation
Schnippel, Kathryn
Unknown Affiliation
Cohn, Susan Ellen
Unknown Affiliation
Statistics
Citations: 5
Authors: 6
Identifiers
Doi:
10.1016/j.jana.2018.01.004
ISSN:
10553290
Study Design
Randomised Control Trial
Participants Gender
Male
Female